Consequences of inducing intrinsic disorder in a high-affinity protein-protein interaction.
The kinetic and thermodynamic consequences of intrinsic disorder in protein-protein recognition are controversial. We address this by inducing one partner of the high-affinity colicin E3 rRNase domain-Im3 complex (Kd ≈ 10(-12) M) to become an intrinsically disordered protein (IDP). Through a variety...
Main Authors: | Papadakos, G, Sharma, A, Lancaster, L, Bowen, R, Kaminska, R, Leech, A, Walker, D, Redfield, C, Kleanthous, K |
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Format: | Journal article |
Language: | English |
Published: |
American Chemical Society
2015
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