Templated interlocked host structures for the recognition and sensing of charged substrates
<p>This thesis describes the synthesis of acyclic, macrocyclic and, in particular, interlocked anion and ion-pair receptors and sensors.</p> <p><strong>Chapter One</strong> will introduce the field of supramolecular chemistry with particular emphasis on areas which are...
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| Format: | Thèse |
| Langue: | English |
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2014
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| Résumé: | <p>This thesis describes the synthesis of acyclic, macrocyclic and, in particular, interlocked anion and ion-pair receptors and sensors.</p> <p><strong>Chapter One</strong> will introduce the field of supramolecular chemistry with particular emphasis on areas which are pertinent to this thesis, including anion receptor design and templated synthesis of interlocked structures.</p> <p><strong>Chapter Two</strong> focuses on the synthesis of new heteroditopic macrocycles functionalised with both cation and anion recognition sites and their incorporation into interlocked architectures. The affinity for a range of anions and ion-pairs is explored <em>via</em> <sup>1</sup>H NMR and UV-visible spectroscopy as well as by X-ray crystallography.</p> <p><strong>Chapter Three</strong> details the incorporation of <em>d</em>- and <em>f</em>-metal luminescent reporter groups into an isophthalamide motif in order to construct acyclic, macrocyclic and [2]rotaxane receptors.</p> <p><strong>Chapter Four</strong> investigates the synthesis of complex higher-order interlocked structures through post-synthetic modification of lower-order interlocked structures.</p> <p><strong>Chapter Five</strong> explores the potential for fluorescent gold nanoparticle conjugates to act as luminescent and colourimetric sensors for chemical warfare agents (CWAs) by employing a fluorescent displacement assay technique.</p> |
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