Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease.

Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease.

UNLABELLED: (11)C-Pittsburgh compound B (PiB) marks Abeta amyloidosis, a key pathogenetic process in Alzheimer disease (AD). The use of (11)C-PiB is limited to centers with a cyclotron. Development of the (18)F-labeled thioflavin derivative of PiB, (18)F-flutemetamol, could hugely increase the avail...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Nelissen, N, Van Laere, K, Thurfjell, L, Owenius, R, Vandenbulcke, M, Koole, M, Bormans, G, Brooks, D, Vandenberghe, R
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2009

Míreanna comhchosúla

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial.
de réir: Vandenberghe, R, et al.
Foilsithe / Cruthaithe: (2010)

Comparison of [18F]Flutemetamol and [11C]Pittsburgh Compound-B in cognitively normal young, cognitively normal elderly, and Alzheimer's disease dementia individuals
de réir: Val J. Lowe, et al.
Foilsithe / Cruthaithe: (2017-01-01)

Binary classification of ¹⁸F-flutemetamol PET using machine learning: comparison with visual reads and structural MRI.
de réir: Vandenberghe, R, et al.
Foilsithe / Cruthaithe: (2013)

Whole-body biodistribution and radiation dosimetry of 18F-GE067: a radioligand for in vivo brain amyloid imaging.
de réir: Koole, M, et al.
Foilsithe / Cruthaithe: (2009)

Longitudinal changes in 18F-Flutemetamol amyloid load in cognitively intact APOE4 carriers versus noncarriers: Methodological considerations
de réir: Emma S. Luckett, et al.
Foilsithe / Cruthaithe: (2023-01-01)

18F-flutemetamol PET/CT imaging in the diagnosis of mild cognitive impairment and Alzheimer's disease：a preliminary study
de réir: LEI Zhe, et al.
Foilsithe / Cruthaithe: (2022-07-01)

Quantitative Evaluation of 18F-Flutemetamol PET in Patients With Cognitive Impairment and Suspected Alzheimer's Disease: A Multicenter Study
de réir: Hiroshi Matsuda, et al.
Foilsithe / Cruthaithe: (2021-01-01)

Abeta amyloid deposition in the language system and how the brain responds.
de réir: Nelissen, N, et al.
Foilsithe / Cruthaithe: (2007)

Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PET
de réir: Yong-Jin Park, et al.
Foilsithe / Cruthaithe: (2025-01-01)

Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques
de réir: Sanna Hellberg, et al.
Foilsithe / Cruthaithe: (2019-03-01)

Comparison of qualitative and quantitative imaging characteristics of [11C]PiB and [18F]flutemetamol in normal control and Alzheimer's subjects
de réir: James M. Mountz, et al.
Foilsithe / Cruthaithe: (2015-01-01)

Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer’s disease with PET imaging agents 18F-flutemetamol and 18F-florbetaben
de réir: Hye Joo Son, et al.
Foilsithe / Cruthaithe: (2018-07-01)

Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated
de réir: Young-Sil An, et al.
Foilsithe / Cruthaithe: (2021-06-01)

Clinical significance of focal ß-amyloid deposition measured by 18F-flutemetamol PET
de réir: Si Eun Kim, et al.
Foilsithe / Cruthaithe: (2020-01-01)

Right hemisphere recruitment during language processing in frontotemporal lobar degeneration and Alzheimer's disease.
de réir: Nelissen, N, et al.
Foilsithe / Cruthaithe: (2011)

Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods
de réir: Mark R. Battle, et al.
Foilsithe / Cruthaithe: (2018-12-01)

Optimized dual-time-window protocols for quantitative [18F]flutemetamol and [18F]florbetaben PET studies
de réir: Fiona Heeman, et al.
Foilsithe / Cruthaithe: (2019-03-01)

Anatomical based reconstruction of dynamic brain PET images using N-[11C]-methylpiperidin-4-YL-proprionate ([11C]-PMP) in elderly normals
de réir: Nelissen, N, et al.
Foilsithe / Cruthaithe: (2007)

Longitudinal Assessment of Amyloid-β Deposition by [18F]-Flutemetamol PET Imaging Compared With [11C]-PIB Across the Spectrum of Alzheimer’s Disease
de réir: Shizuo Hatashita, et al.
Foilsithe / Cruthaithe: (2019-09-01)

Plasma protein biomarkers for the prediction of CSF amyloid and tau and [18F]-flutemetamol PET scan result
de réir: Westwood, S, et al.
Foilsithe / Cruthaithe: (2018)

Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [18F]-Flutemetamol PET Scan Result
de réir: Sarah Westwood, et al.
Foilsithe / Cruthaithe: (2018-12-01)

Temporal and anatomical distribution of 18F-flutemetamol uptake in canine brain using positron emission tomography
de réir: Taesik Yun, et al.
Foilsithe / Cruthaithe: (2020-01-01)

Infrequent false positive [18F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques
de réir: Milos D. Ikonomovic, et al.
Foilsithe / Cruthaithe: (2018-06-01)

Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study
de réir: Laura Michiels, et al.
Foilsithe / Cruthaithe: (2021-05-01)

Software compatibility analysis for quantitative measures of [18F]flutemetamol amyloid PET burden in mild cognitive impairment
de réir: Hugh G. Pemberton, et al.
Foilsithe / Cruthaithe: (2023-05-01)

Automatic lesion detection and segmentation in 18F-flutemetamol positron emission tomography images using deep learning
de réir: Chan Ju Ryu
Foilsithe / Cruthaithe: (2022-12-01)

Drug development in Alzheimer’s disease: the contribution of PET and SPECT
de réir: Lieven Denis Herwig Declercq, et al.
Foilsithe / Cruthaithe: (2016-03-01)

Author Correction: Concordance in detecting amyloid positivity between 18F-florbetaben and 18F-flutemetamol amyloid PET using quantitative and qualitative assessments
de réir: Soo Hyun Cho, et al.
Foilsithe / Cruthaithe: (2021-03-01)

Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
de réir: Lyduine E. Collij, et al.
Foilsithe / Cruthaithe: (2023-11-01)

Cholinergic depletion and basal forebrain volume in primary progressive aphasia
de réir: Jolien Schaeverbeke, et al.
Foilsithe / Cruthaithe: (2017-01-01)

Image reconstruction methods affect software-aided assessment of pathologies of [18F]flutemetamol and [18F]FDG brain-PET examinations in patients with neurodegenerative diseases
de réir: Elin Lindström, et al.
Foilsithe / Cruthaithe: (2020-01-01)

Blood-Brain Transfer of Pittsburgh Compound B in Humans
de réir: Albert eGjedde, et al.
Foilsithe / Cruthaithe: (2013-11-01)

Delivering healthcare to the refugee population in Pittsburgh
de réir: R.M. Hanna, et al.
Foilsithe / Cruthaithe: (2015-03-01)

Comparison of Pittsburgh compound B and florbetapir in cross‐sectional and longitudinal studies
de réir: Yi Su, et al.
Foilsithe / Cruthaithe: (2019-12-01)

A baseball stadium for Pittsburgh
de réir: Anderson, Allan S. (Allan Swan)
Foilsithe / Cruthaithe: (2012)

Economic study of the Pittsburgh region /
de réir: 7859 Pittsburgh Regional Planning Association
Foilsithe / Cruthaithe: (1963)

Proceedings of the Pittsburgh seminar on concurrency
Foilsithe / Cruthaithe: (1985)

Heat transfer - Pittsburgh 1987 /
de réir: Lyczkowski, Robert W., et al.
Foilsithe / Cruthaithe: (1987)

Auditorio público en Pittsburgh
de réir: Edward Cohen
Foilsithe / Cruthaithe: (1962-03-01)

Waite, S. (2017). Teaching queer: Radical possibilities for writing and knowing. Pittsburgh, Pennsylvania: University of Pittsburgh.
de réir: Brittany Amell
Foilsithe / Cruthaithe: (2018-12-01)