Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease.

Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease.

UNLABELLED: (11)C-Pittsburgh compound B (PiB) marks Abeta amyloidosis, a key pathogenetic process in Alzheimer disease (AD). The use of (11)C-PiB is limited to centers with a cyclotron. Development of the (18)F-labeled thioflavin derivative of PiB, (18)F-flutemetamol, could hugely increase the avail...

Bibliografski detalji
Glavni autori:	Nelissen, N, Van Laere, K, Thurfjell, L, Owenius, R, Vandenbulcke, M, Koole, M, Bormans, G, Brooks, D, Vandenberghe, R
Format:	Journal article
Jezik:	English
Izdano:	2009

Slični predmeti

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial.
od: Vandenberghe, R, i dr.
Izdano: (2010)

Comparison of [18F]Flutemetamol and [11C]Pittsburgh Compound-B in cognitively normal young, cognitively normal elderly, and Alzheimer's disease dementia individuals
od: Val J. Lowe, i dr.
Izdano: (2017-01-01)

Binary classification of ¹⁸F-flutemetamol PET using machine learning: comparison with visual reads and structural MRI.
od: Vandenberghe, R, i dr.
Izdano: (2013)

Whole-body biodistribution and radiation dosimetry of 18F-GE067: a radioligand for in vivo brain amyloid imaging.
od: Koole, M, i dr.
Izdano: (2009)

Longitudinal changes in 18F-Flutemetamol amyloid load in cognitively intact APOE4 carriers versus noncarriers: Methodological considerations
od: Emma S. Luckett, i dr.
Izdano: (2023-01-01)

18F-flutemetamol PET/CT imaging in the diagnosis of mild cognitive impairment and Alzheimer's disease：a preliminary study
od: LEI Zhe, i dr.
Izdano: (2022-07-01)

Quantitative Evaluation of 18F-Flutemetamol PET in Patients With Cognitive Impairment and Suspected Alzheimer's Disease: A Multicenter Study
od: Hiroshi Matsuda, i dr.
Izdano: (2021-01-01)

Abeta amyloid deposition in the language system and how the brain responds.
od: Nelissen, N, i dr.
Izdano: (2007)

Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PET
od: Yong-Jin Park, i dr.
Izdano: (2025-01-01)

Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques
od: Sanna Hellberg, i dr.
Izdano: (2019-03-01)

Comparison of qualitative and quantitative imaging characteristics of [11C]PiB and [18F]flutemetamol in normal control and Alzheimer's subjects
od: James M. Mountz, i dr.
Izdano: (2015-01-01)

Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer’s disease with PET imaging agents 18F-flutemetamol and 18F-florbetaben
od: Hye Joo Son, i dr.
Izdano: (2018-07-01)

Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated
od: Young-Sil An, i dr.
Izdano: (2021-06-01)

Clinical significance of focal ß-amyloid deposition measured by 18F-flutemetamol PET
od: Si Eun Kim, i dr.
Izdano: (2020-01-01)

Right hemisphere recruitment during language processing in frontotemporal lobar degeneration and Alzheimer's disease.
od: Nelissen, N, i dr.
Izdano: (2011)

Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods
od: Mark R. Battle, i dr.
Izdano: (2018-12-01)

Optimized dual-time-window protocols for quantitative [18F]flutemetamol and [18F]florbetaben PET studies
od: Fiona Heeman, i dr.
Izdano: (2019-03-01)

Anatomical based reconstruction of dynamic brain PET images using N-[11C]-methylpiperidin-4-YL-proprionate ([11C]-PMP) in elderly normals
od: Nelissen, N, i dr.
Izdano: (2007)

Longitudinal Assessment of Amyloid-β Deposition by [18F]-Flutemetamol PET Imaging Compared With [11C]-PIB Across the Spectrum of Alzheimer’s Disease
od: Shizuo Hatashita, i dr.
Izdano: (2019-09-01)

Plasma protein biomarkers for the prediction of CSF amyloid and tau and [18F]-flutemetamol PET scan result
od: Westwood, S, i dr.
Izdano: (2018)

Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [18F]-Flutemetamol PET Scan Result
od: Sarah Westwood, i dr.
Izdano: (2018-12-01)

Temporal and anatomical distribution of 18F-flutemetamol uptake in canine brain using positron emission tomography
od: Taesik Yun, i dr.
Izdano: (2020-01-01)

Infrequent false positive [18F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques
od: Milos D. Ikonomovic, i dr.
Izdano: (2018-06-01)

Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study
od: Laura Michiels, i dr.
Izdano: (2021-05-01)

Software compatibility analysis for quantitative measures of [18F]flutemetamol amyloid PET burden in mild cognitive impairment
od: Hugh G. Pemberton, i dr.
Izdano: (2023-05-01)

Automatic lesion detection and segmentation in 18F-flutemetamol positron emission tomography images using deep learning
od: Chan Ju Ryu
Izdano: (2022-12-01)

Drug development in Alzheimer’s disease: the contribution of PET and SPECT
od: Lieven Denis Herwig Declercq, i dr.
Izdano: (2016-03-01)

Author Correction: Concordance in detecting amyloid positivity between 18F-florbetaben and 18F-flutemetamol amyloid PET using quantitative and qualitative assessments
od: Soo Hyun Cho, i dr.
Izdano: (2021-03-01)

Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
od: Lyduine E. Collij, i dr.
Izdano: (2023-11-01)

Cholinergic depletion and basal forebrain volume in primary progressive aphasia
od: Jolien Schaeverbeke, i dr.
Izdano: (2017-01-01)

Image reconstruction methods affect software-aided assessment of pathologies of [18F]flutemetamol and [18F]FDG brain-PET examinations in patients with neurodegenerative diseases
od: Elin Lindström, i dr.
Izdano: (2020-01-01)

Blood-Brain Transfer of Pittsburgh Compound B in Humans
od: Albert eGjedde, i dr.
Izdano: (2013-11-01)

Delivering healthcare to the refugee population in Pittsburgh
od: R.M. Hanna, i dr.
Izdano: (2015-03-01)

Comparison of Pittsburgh compound B and florbetapir in cross‐sectional and longitudinal studies
od: Yi Su, i dr.
Izdano: (2019-12-01)

A baseball stadium for Pittsburgh
od: Anderson, Allan S. (Allan Swan)
Izdano: (2012)

Economic study of the Pittsburgh region /
od: 7859 Pittsburgh Regional Planning Association
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Izdano: (1985)

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od: Lyczkowski, Robert W., i dr.
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od: Edward Cohen
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Waite, S. (2017). Teaching queer: Radical possibilities for writing and knowing. Pittsburgh, Pennsylvania: University of Pittsburgh.
od: Brittany Amell
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