Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.

Cancer cell resistance to chemotherapy is often mediated by overexpression of P-glycoprotein, a plasma membrane ABC (ATP-binding cassette) transporter which extrudes cytotoxic drugs at the expense of ATP hydrolysis. P-glycoprotein (ABCB1, according to the human gene nomenclature committee) consists...

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Bibliographic Details
Main Authors: Di Pietro, A, Conseil, G, Pérez-Victoria, J, Dayan, G, Baubichon-Cortay, H, Trompier, D, Steinfels, E, Jault, J, De Wet, H, Maitrejean, M, Comte, G, Boumendjel, A, Mariotte, A, Dumontet, C, McIntosh, D, Goffeau, A, Castanys, S, Gamarro, F, Barron, D
Format: Journal article
Language:English
Published: 2002

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