In-111-labeled EGF is selectively radiotoxic to human breast cancer cells overexpressing EGFR

Библиографические подробности
Главные авторы:	Reilly, R, Kiarash, R, Cameron, R, Porlier, N, Sandhu, J, Hill, R, Vallis, K, Hendler, A, Gariepy, J
Формат:	Conference item
Опубликовано:	2000

111In-labeled EGF is selectively radiotoxic to human breast cancer cells overexpressing EGFR.
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Amplified delivery of indium-111 to EGFR-positive human breast cancer cells.
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The anti-tumor effect of the auger electron-emitting radiopharmaceutical, In-111-hEGF against MDA-MB-468 human breast cancer xenografts is tumor-size dependent.
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Accumulation of 111In-Labelled EGF-Au-PEG Nanoparticles in EGFR-Positive Tumours is Enhanced by Co-administration of Targeting Ligand
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Effect of the EGFR density of breast cancer cells on nuclear importation, in vitro cytotoxicity, and tumor and normal-tissue uptake of [111In]DTPA-hEGF.
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Relationship between induction of phosphorylated H2AX and survival in breast cancer cells exposed to 111In-DTPA-hEGF.
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Computational analysis of the number, area and density of gamma-H2AX foci in breast cancer cells exposed to (111)In-DTPA-hEGF or gamma-rays using Image-J software.
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Antitumor effects and normal tissue toxicity of 111In-labeled epidermal growth factor administered to athymic mice bearing epidermal growth factor receptor-positive human breast cancer xenografts.
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SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo
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111In-labelled polymeric nanoparticles incorporating a ruthenium-based radiosensitizer for EGFR-targeted combination therapy in oesophageal cancer cells
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A phase I trial of In-111-human epidermal growth factor in patients with metastatic EGFR-positive breast cancer
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A phase I clinical trial to evaluate the pharmacokinetics, toxicity and dosimetry of 111-indium-labeled human epidermal growth factor in patients with metastatic breast cancer
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Targeted Delivery of 111In Into the Nuclei of EGFR Overexpressing Cells via Modular Nanotransporters With Anti-EGFR Affibody
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Promising Gene Therapeutics for Salivary Gland Radiotoxicity
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ErbB-2 blockade and prenyltransferase inhibition alter epidermal growth factor and epidermal growth factor receptor trafficking and enhance (111)In-DTPA-hEGF Auger electron radiation therapy.
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EGF-coated gold nanoparticles provide an efficient nano-scale delivery system for the molecular radiotherapy of EGFR-positive cancer.
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A kit formulated under good manufacturing practices for labeling human epidermal growth factor with 111In for radiotherapeutic applications.
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111In-labeled immunoconjugates (ICs) bispecific for the epidermal growth factor receptor (EGFR) and cyclin-dependent kinase inhibitor, p27Kip1.
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SMOC Binds to Pro-EGF, but Does Not Induce Erk Phosphorylation via the EGFR.
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Preclinical pharmacokinetic, biodistribution, toxicology, and dosimetry studies of 111In-DTPA-human epidermal growth factor: an auger electron-emitting radiotherapeutic agent for epidermal growth factor receptor-positive breast cancer.
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EGF Functionalized Polymer-Coated Gold Nanoparticles Promote EGF Photostability and EGFR Internalization for Photothermal Therapy.
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Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation
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Auger electron therapy using In-111-labelled F3 peptide
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Antisense imaging of epidermal growth factor (EGF) induced p21(WAF-1/CIP-1) mRNA in MDA-MB-468 human breast cancer xenografts.
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RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer
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Antitumor Activity of Auger Electron Emitter 111In Delivered by Modular Nanotransporter for Treatment of Bladder Cancer With EGFR Overexpression
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Effect of radiotoxic effect of uranium ore dust on the reproductive system of rats
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Methotrexate, paclitaxel, and doxorubicin radiosensitize HER2-amplified human breast cancer cells to the Auger electron-emitting radiotherapeutic agent (111)In-NLS-trastuzumab.
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Preoperative Localization of a Gastrin-Secreting Tumour by Total Body Imaging with 111Indium-Labelled Pentatreotide
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Phase I trial to evaluate the tumor and normal tissue uptake, radiation dosimetry and safety of (111)In-DTPA-human epidermal growth factor in patients with metastatic EGFR-positive breast cancer.
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Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia
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In-111-labeled EGF is selectively radiotoxic to human breast cancer cells overexpressing EGFR

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