In-111-labeled EGF is selectively radiotoxic to human breast cancer cells overexpressing EGFR

In-111-labeled EGF is selectively radiotoxic to human breast cancer cells overexpressing EGFR

Xehetasun bibliografikoak
Egile Nagusiak:	Reilly, R, Kiarash, R, Cameron, R, Porlier, N, Sandhu, J, Hill, R, Vallis, K, Hendler, A, Gariepy, J
Formatua:	Conference item
Argitaratua:	2000

Antzeko izenburuak

111In-labeled EGF is selectively radiotoxic to human breast cancer cells overexpressing EGFR.
nork: Reilly, R, et al.
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A comparison of EGF and MAb 528 labeled with 111In for imaging human breast cancer.
nork: Reilly, R, et al.
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Comparative antiproliferative effects of (111)In-DTPA-hEGF, chemotherapeutic agents and gamma-radiation on EGFR-positive breast cancer cells.
nork: Chen, P, et al.
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Amplified delivery of indium-111 to EGFR-positive human breast cancer cells.
nork: Wang, J, et al.
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The anti-tumor effect of the auger electron-emitting radiopharmaceutical, In-111-hEGF against MDA-MB-468 human breast cancer xenografts is tumor-size dependent.
nork: Chen, P, et al.
Argitaratua: (2001)

Accumulation of 111In-Labelled EGF-Au-PEG Nanoparticles in EGFR-Positive Tumours is Enhanced by Co-administration of Targeting Ligand
nork: Song, L, et al.
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Effect of the EGFR density of breast cancer cells on nuclear importation, in vitro cytotoxicity, and tumor and normal-tissue uptake of [111In]DTPA-hEGF.
nork: Hu, M, et al.
Argitaratua: (2007)

An 111In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells
nork: Gill, MR, et al.
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Relationship between induction of phosphorylated H2AX and survival in breast cancer cells exposed to 111In-DTPA-hEGF.
nork: Cai, Z, et al.
Argitaratua: (2008)

Computational analysis of the number, area and density of gamma-H2AX foci in breast cancer cells exposed to (111)In-DTPA-hEGF or gamma-rays using Image-J software.
nork: Cai, Z, et al.
Argitaratua: (2009)

Antitumor effects and normal tissue toxicity of 111In-labeled epidermal growth factor administered to athymic mice bearing epidermal growth factor receptor-positive human breast cancer xenografts.
nork: Chen, P, et al.
Argitaratua: (2003)

SPECT imaging and biodistribution studies of 111In-EGF-Au-PEG nanoparticles in vivo
nork: Song, L, et al.
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111In-labelled polymeric nanoparticles incorporating a ruthenium-based radiosensitizer for EGFR-targeted combination therapy in oesophageal cancer cells
nork: Gill, M, et al.
Argitaratua: (2018)

A phase I trial of In-111-human epidermal growth factor in patients with metastatic EGFR-positive breast cancer
nork: Vallis, K, et al.
Argitaratua: (2008)

A phase I clinical trial to evaluate the pharmacokinetics, toxicity and dosimetry of 111-indium-labeled human epidermal growth factor in patients with metastatic breast cancer
nork: Vallis, K, et al.
Argitaratua: (2005)

Targeted Delivery of 111In Into the Nuclei of EGFR Overexpressing Cells via Modular Nanotransporters With Anti-EGFR Affibody
nork: Tatiana S. Karyagina, et al.
Argitaratua: (2020-03-01)

Drug-encapsulating EGF-sensitive liposomes for EGF-overexpressing cancer therapies
nork: Wong, Albert, S.M. Massachusetts Institute of Technology
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(111)In-labeled trastuzumab (Herceptin) modified with nuclear localization sequences (NLS): an Auger electron-emitting radiotherapeutic agent for HER2/neu-amplified breast cancer.
nork: Costantini, D, et al.
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Promising Gene Therapeutics for Salivary Gland Radiotoxicity
nork: Renjith Parameswaran Nair, et al.
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ErbB-2 blockade and prenyltransferase inhibition alter epidermal growth factor and epidermal growth factor receptor trafficking and enhance (111)In-DTPA-hEGF Auger electron radiation therapy.
nork: Cornelissen, B, et al.
Argitaratua: (2011)

EGF-coated gold nanoparticles provide an efficient nano-scale delivery system for the molecular radiotherapy of EGFR-positive cancer.
nork: Song, L, et al.
Argitaratua: (2016)

A phase I study of Tc-99m-h-R3 monoclonal antibody (DiaCIM (R)), a humanized monoclonal antibody (mAB) for imaging EGFR-positive malignancies.
nork: Reilly, R, et al.
Argitaratua: (2002)

A kit formulated under good manufacturing practices for labeling human epidermal growth factor with 111In for radiotherapeutic applications.
nork: Reilly, R, et al.
Argitaratua: (2004)

111In-labeled immunoconjugates (ICs) bispecific for the epidermal growth factor receptor (EGFR) and cyclin-dependent kinase inhibitor, p27Kip1.
nork: Cornelissen, B, et al.
Argitaratua: (2009)

SMOC Binds to Pro-EGF, but Does Not Induce Erk Phosphorylation via the EGFR.
nork: J Terrig Thomas, et al.
Argitaratua: (2016-01-01)

Preclinical pharmacokinetic, biodistribution, toxicology, and dosimetry studies of 111In-DTPA-human epidermal growth factor: an auger electron-emitting radiotherapeutic agent for epidermal growth factor receptor-positive breast cancer.
nork: Reilly, R, et al.
Argitaratua: (2006)

EGF Functionalized Polymer-Coated Gold Nanoparticles Promote EGF Photostability and EGFR Internalization for Photothermal Therapy.
nork: Catarina Oliveira Silva, et al.
Argitaratua: (2016-01-01)

Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation
nork: Owen, J, et al.
Argitaratua: (2019)

Auger electron therapy using In-111-labelled F3 peptide
nork: Cornelissen, B, et al.
Argitaratua: (2011)

Antisense imaging of epidermal growth factor (EGF) induced p21(WAF-1/CIP-1) mRNA in MDA-MB-468 human breast cancer xenografts.
nork: Wang, J, et al.
Argitaratua: (2002)

RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer
nork: Marzia Di Donato, et al.
Argitaratua: (2023-10-01)

Antitumor Activity of Auger Electron Emitter 111In Delivered by Modular Nanotransporter for Treatment of Bladder Cancer With EGFR Overexpression
nork: Andrey A. Rosenkranz, et al.
Argitaratua: (2018-11-01)

Molecular Biomarkers for Predicting Cancer Patient Radiosensitivity and Radiotoxicity in Clinical Practice
nork: Angeliki Gkikoudi, et al.
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Effect of radiotoxic effect of uranium ore dust on the reproductive system of rats
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Methotrexate, paclitaxel, and doxorubicin radiosensitize HER2-amplified human breast cancer cells to the Auger electron-emitting radiotherapeutic agent (111)In-NLS-trastuzumab.
nork: Costantini, D, et al.
Argitaratua: (2010)

Preoperative Localization of a Gastrin-Secreting Tumour by Total Body Imaging with 111Indium-Labelled Pentatreotide
nork: Humera Ali, et al.
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Phase I trial to evaluate the tumor and normal tissue uptake, radiation dosimetry and safety of (111)In-DTPA-human epidermal growth factor in patients with metastatic EGFR-positive breast cancer.
nork: Vallis, K, et al.
Argitaratua: (2014)

Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia
nork: Indira Kosovic, et al.
Argitaratua: (2017-01-01)

Folliculin Interacts with Rab35 to Regulate EGF-Induced EGFR Degradation
nork: Jianchao Zheng, et al.
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HCC-derived EGFR mutants are functioning, EGF-dependent, and erlotinib-resistant
nork: Natthaporn Sueangoen, et al.
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