5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases. Using a representative 2OG oxygenase panel, we compare the inhibitory activities of 5-carboxy-8-hydroxyquinoline (IOX1) and 4-carboxy-8-hydroxyquinoline (4C8HQ) with that of two other commonly used 2OG oxygenase...

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Detalles Bibliográficos
Autores principales:	Hopkinson, R, Tumber, A, Yapp, C, Chowdhury, R, Aik, W, Che, K, Li, X, Kristensen, J, King, O, Chan, M, Yeoh, K, Choi, H, Walport, L, Thinnes, C, Bush, J, Lejeune, C, Rydzik, A, Rose, N, Bagg, E, McDonough, M, Krojer, T, Yue, W, Ng, S, Olsen, L, Brennan, P
Formato:	Journal article
Lenguaje:	English
Publicado:	2013

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

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