A higher Mediterranean diet score, including unprocessed red meat, is associated with reduced risk of central nervous system demyelination in a case-control study of Australian adults
<p><strong>Background</strong></p> <p>The evidence associating diet and risk of multiple sclerosis (MS) is inconclusive.</p> <p><strong>Objectives</strong></p> <p>The aim of this study was to investigate associations between a Medite...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2019
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| _version_ | 1826294581796274176 |
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| author | Black, LJ Baker, K Ponsonby, A-L van Der Mei, I Lucas, RM Pereira, G Ausimmune Investigator Group |
| author2 | Dwyer, T |
| author_facet | Dwyer, T Black, LJ Baker, K Ponsonby, A-L van Der Mei, I Lucas, RM Pereira, G Ausimmune Investigator Group |
| author_sort | Black, LJ |
| collection | OXFORD |
| description | <p><strong>Background</strong></p>
<p>The evidence associating diet and risk of multiple sclerosis (MS) is inconclusive.</p>
<p><strong>Objectives</strong></p>
<p>The aim of this study was to investigate associations between a Mediterranean diet and risk of a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS.</p>
<p><strong>Methods</strong></p>
<p>We used data from the 2003–2006 Ausimmune Study, an Australian multicenter, case-control study examining environmental risk factors for FCD, with participants matched on age, sex, and study region (282 cases, 558 controls; 18–59 y old; 78% female). The alternate Mediterranean diet score (aMED) was calculated based on data from a food-frequency questionnaire. We created a modified version of the aMED (aMED-Red) where ∼1 daily serving (65 g) of unprocessed red meat received 1 point. All other components remained the same as aMED. Conditional logistic regression (254 cases, 451 controls) was used to test associations between aMED and aMED-Red scores and categories and risk of FCD, adjusting for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, education, total energy intake, and dietary underreporting.</p>
<p><strong>Results</strong></p>
<p>There was no statistically significant association between aMED and risk of FCD [per 1-SD increase in aMED score: adjusted odds ratio (aOR): 0.89; 95% CI: 0.75, 1.06; P = 0.181]. There was evidence of a nonlinear relation between aMED-Red and risk of FCD when a quadratic term was used (P = 0.016). Compared with the lowest category of aMED-Red, higher categories were significantly associated with reduced risk of FCD, corresponding to a 37% (aOR: 0.63; 95% CI: 0.41, 0.98; P = 0.039), 52% (aOR: 0.48; 95% CI: 0.28, 0.83; P = 0.009), and 42% (aOR: 0.58; 95% CI: 0.35, 0.96; P = 0.034) reduced risk of FCD in categories 2, 3, and 4, respectively.</p>
<p><strong>Conclusions</strong></p>
<p>A Mediterranean diet, including unprocessed red meat, was associated with reduced risk of FCD in this Australian adult population. The addition of unprocessed red meat to a Mediterranean diet may be beneficial for those at high risk of MS.</p> |
| first_indexed | 2024-03-07T03:47:53Z |
| format | Journal article |
| id | oxford-uuid:c02490e7-2f30-4cb9-bf9f-4625acd59d6b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:47:53Z |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:c02490e7-2f30-4cb9-bf9f-4625acd59d6b2022-03-27T05:52:33ZA higher Mediterranean diet score, including unprocessed red meat, is associated with reduced risk of central nervous system demyelination in a case-control study of Australian adultsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c02490e7-2f30-4cb9-bf9f-4625acd59d6bEnglishSymplectic Elements at OxfordOxford University Press2019Black, LJBaker, KPonsonby, A-Lvan Der Mei, ILucas, RMPereira, GAusimmune Investigator GroupDwyer, T<p><strong>Background</strong></p> <p>The evidence associating diet and risk of multiple sclerosis (MS) is inconclusive.</p> <p><strong>Objectives</strong></p> <p>The aim of this study was to investigate associations between a Mediterranean diet and risk of a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS.</p> <p><strong>Methods</strong></p> <p>We used data from the 2003–2006 Ausimmune Study, an Australian multicenter, case-control study examining environmental risk factors for FCD, with participants matched on age, sex, and study region (282 cases, 558 controls; 18–59 y old; 78% female). The alternate Mediterranean diet score (aMED) was calculated based on data from a food-frequency questionnaire. We created a modified version of the aMED (aMED-Red) where ∼1 daily serving (65 g) of unprocessed red meat received 1 point. All other components remained the same as aMED. Conditional logistic regression (254 cases, 451 controls) was used to test associations between aMED and aMED-Red scores and categories and risk of FCD, adjusting for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, education, total energy intake, and dietary underreporting.</p> <p><strong>Results</strong></p> <p>There was no statistically significant association between aMED and risk of FCD [per 1-SD increase in aMED score: adjusted odds ratio (aOR): 0.89; 95% CI: 0.75, 1.06; P = 0.181]. There was evidence of a nonlinear relation between aMED-Red and risk of FCD when a quadratic term was used (P = 0.016). Compared with the lowest category of aMED-Red, higher categories were significantly associated with reduced risk of FCD, corresponding to a 37% (aOR: 0.63; 95% CI: 0.41, 0.98; P = 0.039), 52% (aOR: 0.48; 95% CI: 0.28, 0.83; P = 0.009), and 42% (aOR: 0.58; 95% CI: 0.35, 0.96; P = 0.034) reduced risk of FCD in categories 2, 3, and 4, respectively.</p> <p><strong>Conclusions</strong></p> <p>A Mediterranean diet, including unprocessed red meat, was associated with reduced risk of FCD in this Australian adult population. The addition of unprocessed red meat to a Mediterranean diet may be beneficial for those at high risk of MS.</p> |
| spellingShingle | Black, LJ Baker, K Ponsonby, A-L van Der Mei, I Lucas, RM Pereira, G Ausimmune Investigator Group A higher Mediterranean diet score, including unprocessed red meat, is associated with reduced risk of central nervous system demyelination in a case-control study of Australian adults |
| title | A higher Mediterranean diet score, including unprocessed red meat, is associated with reduced risk of central nervous system demyelination in a case-control study of Australian adults |
| title_full | A higher Mediterranean diet score, including unprocessed red meat, is associated with reduced risk of central nervous system demyelination in a case-control study of Australian adults |
| title_fullStr | A higher Mediterranean diet score, including unprocessed red meat, is associated with reduced risk of central nervous system demyelination in a case-control study of Australian adults |
| title_full_unstemmed | A higher Mediterranean diet score, including unprocessed red meat, is associated with reduced risk of central nervous system demyelination in a case-control study of Australian adults |
| title_short | A higher Mediterranean diet score, including unprocessed red meat, is associated with reduced risk of central nervous system demyelination in a case-control study of Australian adults |
| title_sort | higher mediterranean diet score including unprocessed red meat is associated with reduced risk of central nervous system demyelination in a case control study of australian adults |
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