Alternative splicing: Global insights: Minireview
Following the original reports of pre-mRNA splicing in 1977, it was quickly realized that splicing together of different combinations of splice sites - alternative splicing- allows individual genes to generate more than one mRNA isoform. The full extent of alternative splicing only began to be revea...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797092600668225536 |
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| author | Hallegger, M Llorian, M Smith, C |
| author_facet | Hallegger, M Llorian, M Smith, C |
| author_sort | Hallegger, M |
| collection | OXFORD |
| description | Following the original reports of pre-mRNA splicing in 1977, it was quickly realized that splicing together of different combinations of splice sites - alternative splicing- allows individual genes to generate more than one mRNA isoform. The full extent of alternative splicing only began to be revealed once large-scale genome and transcriptome sequencing projects began, rapidly revealing that alternative splicing is the rule rather than the exception. Recent technical innovations have facilitated the investigation of alternative splicing at a global scale. Splice-sensitive microarray platforms and deep sequencing allow quantitative profiling of very large numbers of alternative splicing events, whereas global analysis of the targets of RNA binding proteins reveals the regulatory networks involved in post-transcriptional gene control. Combined with sophisticated computational analysis, these new approaches are beginning to reveal the so-called 'RNA code' that underlies tissue and developmentally regulated alternative splicing, and that can be disrupted by disease-causing mutations. © 2010 FEBS. |
| first_indexed | 2024-03-07T03:48:18Z |
| format | Journal article |
| id | oxford-uuid:c04a5adf-7968-4050-bf99-9aa1ab08b54c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:48:18Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:c04a5adf-7968-4050-bf99-9aa1ab08b54c2022-03-27T05:53:30ZAlternative splicing: Global insights: MinireviewJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c04a5adf-7968-4050-bf99-9aa1ab08b54cEnglishSymplectic Elements at Oxford2010Hallegger, MLlorian, MSmith, CFollowing the original reports of pre-mRNA splicing in 1977, it was quickly realized that splicing together of different combinations of splice sites - alternative splicing- allows individual genes to generate more than one mRNA isoform. The full extent of alternative splicing only began to be revealed once large-scale genome and transcriptome sequencing projects began, rapidly revealing that alternative splicing is the rule rather than the exception. Recent technical innovations have facilitated the investigation of alternative splicing at a global scale. Splice-sensitive microarray platforms and deep sequencing allow quantitative profiling of very large numbers of alternative splicing events, whereas global analysis of the targets of RNA binding proteins reveals the regulatory networks involved in post-transcriptional gene control. Combined with sophisticated computational analysis, these new approaches are beginning to reveal the so-called 'RNA code' that underlies tissue and developmentally regulated alternative splicing, and that can be disrupted by disease-causing mutations. © 2010 FEBS. |
| spellingShingle | Hallegger, M Llorian, M Smith, C Alternative splicing: Global insights: Minireview |
| title | Alternative splicing: Global insights: Minireview |
| title_full | Alternative splicing: Global insights: Minireview |
| title_fullStr | Alternative splicing: Global insights: Minireview |
| title_full_unstemmed | Alternative splicing: Global insights: Minireview |
| title_short | Alternative splicing: Global insights: Minireview |
| title_sort | alternative splicing global insights minireview |
| work_keys_str_mv | AT halleggerm alternativesplicingglobalinsightsminireview AT llorianm alternativesplicingglobalinsightsminireview AT smithc alternativesplicingglobalinsightsminireview |