Effect of intravenous infusion of atriopeptin 3 on immediate renal allograft function.
Thirty-eight recipients of nineteen pairs of cadaveric kidneys were entered into a double-blind randomized study in which one recipient received a 12-hour intravenous infusion of Atriopeptin III (AP-3), a synthetic analogue of atrial natriuretic factor, commencing at release of the vascular clamps,...
| Váldodahkkit: | , , , , , |
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| Materiálatiipa: | Journal article |
| Giella: | English |
| Almmustuhtton: |
1991
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| _version_ | 1826294624715538432 |
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| author | Ratcliffe, P Richardson, A Kirby, J Moyses, C Shelton, JR Morris, P |
| author_facet | Ratcliffe, P Richardson, A Kirby, J Moyses, C Shelton, JR Morris, P |
| author_sort | Ratcliffe, P |
| collection | OXFORD |
| description | Thirty-eight recipients of nineteen pairs of cadaveric kidneys were entered into a double-blind randomized study in which one recipient received a 12-hour intravenous infusion of Atriopeptin III (AP-3), a synthetic analogue of atrial natriuretic factor, commencing at release of the vascular clamps, and the other received a placebo infusion. In an initial dose ranging study, successive groups of six kidneys (3 pairs) were randomized to receive each of 0.0125, 0.025, 0.05 micrograms/kg/min AP-3 or placebo. Thereafter 20 kidneys (10 pairs) received 0.1 micrograms/kg/min or placebo. There was no discernable effect of AP-3 on allograft creatinine clearance or sodium excretion either when the highest dose of AP-3 was considered alone or when all doses were considered together. Averaged creatinine clearance over the period 0 to 24 hours after transplantation was 20.1 +/- 14.7 ml/min in patients receiving active treatment and 18.2 +/- 13.7 ml/min in those receiving placebo. Thus, despite the documentation of a protective effect of atrial natriuretic factor in animal models of renal ischemia, it is unlikely that intravenous infusion of AP-3 in this dose range will be of benefit in improving immediate renal allograft graft function. |
| first_indexed | 2024-03-07T03:48:33Z |
| format | Journal article |
| id | oxford-uuid:c0661d29-23bd-414b-a16f-c48058af722c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:48:33Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:c0661d29-23bd-414b-a16f-c48058af722c2022-03-27T05:54:06ZEffect of intravenous infusion of atriopeptin 3 on immediate renal allograft function.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c0661d29-23bd-414b-a16f-c48058af722cEnglishSymplectic Elements at Oxford1991Ratcliffe, PRichardson, AKirby, JMoyses, CShelton, JRMorris, PThirty-eight recipients of nineteen pairs of cadaveric kidneys were entered into a double-blind randomized study in which one recipient received a 12-hour intravenous infusion of Atriopeptin III (AP-3), a synthetic analogue of atrial natriuretic factor, commencing at release of the vascular clamps, and the other received a placebo infusion. In an initial dose ranging study, successive groups of six kidneys (3 pairs) were randomized to receive each of 0.0125, 0.025, 0.05 micrograms/kg/min AP-3 or placebo. Thereafter 20 kidneys (10 pairs) received 0.1 micrograms/kg/min or placebo. There was no discernable effect of AP-3 on allograft creatinine clearance or sodium excretion either when the highest dose of AP-3 was considered alone or when all doses were considered together. Averaged creatinine clearance over the period 0 to 24 hours after transplantation was 20.1 +/- 14.7 ml/min in patients receiving active treatment and 18.2 +/- 13.7 ml/min in those receiving placebo. Thus, despite the documentation of a protective effect of atrial natriuretic factor in animal models of renal ischemia, it is unlikely that intravenous infusion of AP-3 in this dose range will be of benefit in improving immediate renal allograft graft function. |
| spellingShingle | Ratcliffe, P Richardson, A Kirby, J Moyses, C Shelton, JR Morris, P Effect of intravenous infusion of atriopeptin 3 on immediate renal allograft function. |
| title | Effect of intravenous infusion of atriopeptin 3 on immediate renal allograft function. |
| title_full | Effect of intravenous infusion of atriopeptin 3 on immediate renal allograft function. |
| title_fullStr | Effect of intravenous infusion of atriopeptin 3 on immediate renal allograft function. |
| title_full_unstemmed | Effect of intravenous infusion of atriopeptin 3 on immediate renal allograft function. |
| title_short | Effect of intravenous infusion of atriopeptin 3 on immediate renal allograft function. |
| title_sort | effect of intravenous infusion of atriopeptin 3 on immediate renal allograft function |
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