Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria.
In eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h. All patients were clinically cured--mea...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1985
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| _version_ | 1826294636055887872 |
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| author | Looareesuwan, S Phillips, R White, N Karbwang, J Benjasurat, Y Attanath, P Warrell, D |
| author_facet | Looareesuwan, S Phillips, R White, N Karbwang, J Benjasurat, Y Attanath, P Warrell, D |
| author_sort | Looareesuwan, S |
| collection | OXFORD |
| description | In eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h. All patients were clinically cured--mean fever clearance time 37.8 h (range 24-60), mean parasite clearance time 64.9 h (18-164). There were no serious toxic effects. 33 patients aged over 5 years with uncomplicated falciparum malaria were given oral amodiaquine dihydrochloride (mean total dose 41 mg base/kg over 3 days) combined with erythromycin estolate (mean dose 48 mg base/kg daily for 5 days). 2 patients failed to respond. In the other 31 patients mean fever clearance time was 55.9 h (range 10-104) and mean parasite clearance time was 65.4 h (40-120). In both studies, more than half the patients followed-up had recurrent parasitaemia but reinfection could not be excluded. Parasites isolated from 18 patients were highly resistant to chloroquine in vitro. |
| first_indexed | 2024-03-07T03:48:44Z |
| format | Journal article |
| id | oxford-uuid:c07848e9-28c1-4893-b18a-0df60a9fa117 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:48:44Z |
| publishDate | 1985 |
| record_format | dspace |
| spelling | oxford-uuid:c07848e9-28c1-4893-b18a-0df60a9fa1172022-03-27T05:54:32ZIntravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c07848e9-28c1-4893-b18a-0df60a9fa117EnglishSymplectic Elements at Oxford1985Looareesuwan, SPhillips, RWhite, NKarbwang, JBenjasurat, YAttanath, PWarrell, DIn eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h. All patients were clinically cured--mean fever clearance time 37.8 h (range 24-60), mean parasite clearance time 64.9 h (18-164). There were no serious toxic effects. 33 patients aged over 5 years with uncomplicated falciparum malaria were given oral amodiaquine dihydrochloride (mean total dose 41 mg base/kg over 3 days) combined with erythromycin estolate (mean dose 48 mg base/kg daily for 5 days). 2 patients failed to respond. In the other 31 patients mean fever clearance time was 55.9 h (range 10-104) and mean parasite clearance time was 65.4 h (40-120). In both studies, more than half the patients followed-up had recurrent parasitaemia but reinfection could not be excluded. Parasites isolated from 18 patients were highly resistant to chloroquine in vitro. |
| spellingShingle | Looareesuwan, S Phillips, R White, N Karbwang, J Benjasurat, Y Attanath, P Warrell, D Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. |
| title | Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. |
| title_full | Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. |
| title_fullStr | Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. |
| title_full_unstemmed | Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. |
| title_short | Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. |
| title_sort | intravenous amodiaquine and oral amodiaquine erythromycin in the treatment of chloroquine resistant falciparum malaria |
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