Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington’s disease

Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington’s disease

Circadian deficits in Huntington’s disease (HD) are recapitulated in both fragment (R6/2) and full- length (Q175) mouse models of HD. Circadian rhythms are regulated by the suprachiasmatic nuclei (SCN) in the hypothalamus, which are primarily entrained by light detected by the retina. The SCN rec...

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Bibliographic Details
Main Authors:	Ouk, K, Hughes, S, Pothecary, C, Peirson, S, Morton, A
Format:	Journal article
Published:	Oxford University Press 2016

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