Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington’s disease

Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington’s disease

Circadian deficits in Huntington’s disease (HD) are recapitulated in both fragment (R6/2) and full- length (Q175) mouse models of HD. Circadian rhythms are regulated by the suprachiasmatic nuclei (SCN) in the hypothalamus, which are primarily entrained by light detected by the retina. The SCN rec...

書目詳細資料
Main Authors:	Ouk, K, Hughes, S, Pothecary, C, Peirson, S, Morton, A
格式:	Journal article
出版:	Oxford University Press 2016

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