Bacterial flagellar motor.
The bacterial flagellar motor is a reversible rotary nano-machine, about 45 nm in diameter, embedded in the bacterial cell envelope. It is powered by the flux of H+ or Na+ ions across the cytoplasmic membrane driven by an electrochemical gradient, the proton-motive force or the sodium-motive force....
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797092649717465088 |
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| author | Sowa, Y Berry, R |
| author_facet | Sowa, Y Berry, R |
| author_sort | Sowa, Y |
| collection | OXFORD |
| description | The bacterial flagellar motor is a reversible rotary nano-machine, about 45 nm in diameter, embedded in the bacterial cell envelope. It is powered by the flux of H+ or Na+ ions across the cytoplasmic membrane driven by an electrochemical gradient, the proton-motive force or the sodium-motive force. Each motor rotates a helical filament at several hundreds of revolutions per second (hertz). In many species, the motor switches direction stochastically, with the switching rates controlled by a network of sensory and signalling proteins. The bacterial flagellar motor was confirmed as a rotary motor in the early 1970s, the first direct observation of the function of a single molecular motor. However, because of the large size and complexity of the motor, much remains to be discovered, in particular, the structural details of the torque-generating mechanism. This review outlines what has been learned about the structure and function of the motor using a combination of genetics, single-molecule and biophysical techniques, with a focus on recent results and single-molecule techniques. |
| first_indexed | 2024-03-07T03:49:02Z |
| format | Journal article |
| id | oxford-uuid:c091f0e7-308b-4c7d-99e0-df7594a5615b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:49:02Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:c091f0e7-308b-4c7d-99e0-df7594a5615b2022-03-27T05:55:17ZBacterial flagellar motor.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c091f0e7-308b-4c7d-99e0-df7594a5615bEnglishSymplectic Elements at Oxford2008Sowa, YBerry, RThe bacterial flagellar motor is a reversible rotary nano-machine, about 45 nm in diameter, embedded in the bacterial cell envelope. It is powered by the flux of H+ or Na+ ions across the cytoplasmic membrane driven by an electrochemical gradient, the proton-motive force or the sodium-motive force. Each motor rotates a helical filament at several hundreds of revolutions per second (hertz). In many species, the motor switches direction stochastically, with the switching rates controlled by a network of sensory and signalling proteins. The bacterial flagellar motor was confirmed as a rotary motor in the early 1970s, the first direct observation of the function of a single molecular motor. However, because of the large size and complexity of the motor, much remains to be discovered, in particular, the structural details of the torque-generating mechanism. This review outlines what has been learned about the structure and function of the motor using a combination of genetics, single-molecule and biophysical techniques, with a focus on recent results and single-molecule techniques. |
| spellingShingle | Sowa, Y Berry, R Bacterial flagellar motor. |
| title | Bacterial flagellar motor. |
| title_full | Bacterial flagellar motor. |
| title_fullStr | Bacterial flagellar motor. |
| title_full_unstemmed | Bacterial flagellar motor. |
| title_short | Bacterial flagellar motor. |
| title_sort | bacterial flagellar motor |
| work_keys_str_mv | AT soway bacterialflagellarmotor AT berryr bacterialflagellarmotor |