Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.

The retinoblastoma susceptibility protein, Rb, has a key role in regulating cell-cycle progression via interactions involving the central "pocket" and C-terminal regions. While the N-terminal domain of Rb is dispensable for this function, it is nonetheless strongly conserved and harbors mi...

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Detalhes bibliográficos
Main Authors: Hassler, M, Singh, S, Yue, W, Luczynski, M, Lakbir, R, Sanchez-Sanchez, F, Bader, T, Pearl, L, Mittnacht, S
Formato: Journal article
Idioma:English
Publicado em: 2007

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