Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.
The retinoblastoma susceptibility protein, Rb, has a key role in regulating cell-cycle progression via interactions involving the central "pocket" and C-terminal regions. While the N-terminal domain of Rb is dispensable for this function, it is nonetheless strongly conserved and harbors mi...
Main Authors: | Hassler, M, Singh, S, Yue, W, Luczynski, M, Lakbir, R, Sanchez-Sanchez, F, Bader, T, Pearl, L, Mittnacht, S |
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Formato: | Journal article |
Idioma: | English |
Publicado em: |
2007
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