An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells.

An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells.

GATA-1 is a tissue-specific transcription factor that is essential for the production of red blood cells. Here we show that overexpression of GATA-1 in erythroid cells inhibits their differentiation, leading to a lethal anaemia. Using chromosome-X-inactivation of a GATA-1 transgene and chimaeric ani...

Podrobná bibliografie
Hlavní autoři:	Whyatt, D, Lindeboom, F, Karis, A, Ferreira, R, Milot, E, Hendriks, R, De Bruijn, M, Langeveld, A, Gribnau, J, Grosveld, F, Philipsen, S
Médium:	Journal article
Jazyk:	English
Vydáno:	2000

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