Pathogen-based precision medicine for drug-resistant tuberculosis
The implementation of next generation sequencing techniques, such as whole genome sequencing (WGS), in tuberculosis (TB) research has enabled timely, cost-effective, and comprehensive insights into the genetic repertoire of the human pathogens of the Mycobacterium tuberculosis complex (MTBC). WGS da...
| Main Authors: | , , , , , |
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| Format: | Journal article |
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Public Library of Science
2018
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| _version_ | 1826294683343519744 |
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| author | Groschel, M Walker, T Van Der Werf, T Lange, C Niemann, S Merker, M |
| author_facet | Groschel, M Walker, T Van Der Werf, T Lange, C Niemann, S Merker, M |
| author_sort | Groschel, M |
| collection | OXFORD |
| description | The implementation of next generation sequencing techniques, such as whole genome sequencing (WGS), in tuberculosis (TB) research has enabled timely, cost-effective, and comprehensive insights into the genetic repertoire of the human pathogens of the Mycobacterium tuberculosis complex (MTBC). WGS data allow for detailed epidemiological analysis based on genomic distance of the MTBC strains under investigation, e.g. for tracing outbreaks; it can accelerate diagnostics by predicting drug resistance from a mutation catalogue (figure 1). Indeed, specific mutations even permit predictions on the possible clinical treatment course and outcome. |
| first_indexed | 2024-03-07T03:49:28Z |
| format | Journal article |
| id | oxford-uuid:c0b40082-aa4f-418b-a760-09550eeadec6 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:49:28Z |
| publishDate | 2018 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:c0b40082-aa4f-418b-a760-09550eeadec62022-03-27T05:56:22ZPathogen-based precision medicine for drug-resistant tuberculosisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c0b40082-aa4f-418b-a760-09550eeadec6Symplectic Elements at OxfordPublic Library of Science2018Groschel, MWalker, TVan Der Werf, TLange, CNiemann, SMerker, MThe implementation of next generation sequencing techniques, such as whole genome sequencing (WGS), in tuberculosis (TB) research has enabled timely, cost-effective, and comprehensive insights into the genetic repertoire of the human pathogens of the Mycobacterium tuberculosis complex (MTBC). WGS data allow for detailed epidemiological analysis based on genomic distance of the MTBC strains under investigation, e.g. for tracing outbreaks; it can accelerate diagnostics by predicting drug resistance from a mutation catalogue (figure 1). Indeed, specific mutations even permit predictions on the possible clinical treatment course and outcome. |
| spellingShingle | Groschel, M Walker, T Van Der Werf, T Lange, C Niemann, S Merker, M Pathogen-based precision medicine for drug-resistant tuberculosis |
| title | Pathogen-based precision medicine for drug-resistant tuberculosis |
| title_full | Pathogen-based precision medicine for drug-resistant tuberculosis |
| title_fullStr | Pathogen-based precision medicine for drug-resistant tuberculosis |
| title_full_unstemmed | Pathogen-based precision medicine for drug-resistant tuberculosis |
| title_short | Pathogen-based precision medicine for drug-resistant tuberculosis |
| title_sort | pathogen based precision medicine for drug resistant tuberculosis |
| work_keys_str_mv | AT groschelm pathogenbasedprecisionmedicinefordrugresistanttuberculosis AT walkert pathogenbasedprecisionmedicinefordrugresistanttuberculosis AT vanderwerft pathogenbasedprecisionmedicinefordrugresistanttuberculosis AT langec pathogenbasedprecisionmedicinefordrugresistanttuberculosis AT niemanns pathogenbasedprecisionmedicinefordrugresistanttuberculosis AT merkerm pathogenbasedprecisionmedicinefordrugresistanttuberculosis |