Resistance of cardiac cells to NCX knockout: a model study.
The effects of NCX knockout were determined in a variety of cardiac cell models. Those of the mouse and rat ventricles, and of atrial cells in other species behave similarly to the experiments on mouse ventricle showing only small effects, and considerable tolerance of NCX knockout. Models of ventri...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1826294698254270464 |
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| author | Noble, D Sarai, N Noble, P Kobayashi, T Matsuoka, S Noma, A |
| author_facet | Noble, D Sarai, N Noble, P Kobayashi, T Matsuoka, S Noma, A |
| author_sort | Noble, D |
| collection | OXFORD |
| description | The effects of NCX knockout were determined in a variety of cardiac cell models. Those of the mouse and rat ventricles, and of atrial cells in other species behave similarly to the experiments on mouse ventricle showing only small effects, and considerable tolerance of NCX knockout. Models of ventricular cells with high action potential plateaus, however, are more sensitive and require compensatory mechanisms to adjust other conductance parameters to enable the cells to resist NCX knockout. The effects can therefore be expected to be species-specific, and it is not possible to extrapolate the mouse results to those that may occur in the Guinea pig or human. |
| first_indexed | 2024-03-07T03:49:42Z |
| format | Journal article |
| id | oxford-uuid:c0c97737-21a2-4830-8c5f-23905c762136 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:49:42Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:c0c97737-21a2-4830-8c5f-23905c7621362022-03-27T05:56:57ZResistance of cardiac cells to NCX knockout: a model study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c0c97737-21a2-4830-8c5f-23905c762136EnglishSymplectic Elements at Oxford2007Noble, DSarai, NNoble, PKobayashi, TMatsuoka, SNoma, AThe effects of NCX knockout were determined in a variety of cardiac cell models. Those of the mouse and rat ventricles, and of atrial cells in other species behave similarly to the experiments on mouse ventricle showing only small effects, and considerable tolerance of NCX knockout. Models of ventricular cells with high action potential plateaus, however, are more sensitive and require compensatory mechanisms to adjust other conductance parameters to enable the cells to resist NCX knockout. The effects can therefore be expected to be species-specific, and it is not possible to extrapolate the mouse results to those that may occur in the Guinea pig or human. |
| spellingShingle | Noble, D Sarai, N Noble, P Kobayashi, T Matsuoka, S Noma, A Resistance of cardiac cells to NCX knockout: a model study. |
| title | Resistance of cardiac cells to NCX knockout: a model study. |
| title_full | Resistance of cardiac cells to NCX knockout: a model study. |
| title_fullStr | Resistance of cardiac cells to NCX knockout: a model study. |
| title_full_unstemmed | Resistance of cardiac cells to NCX knockout: a model study. |
| title_short | Resistance of cardiac cells to NCX knockout: a model study. |
| title_sort | resistance of cardiac cells to ncx knockout a model study |
| work_keys_str_mv | AT nobled resistanceofcardiaccellstoncxknockoutamodelstudy AT sarain resistanceofcardiaccellstoncxknockoutamodelstudy AT noblep resistanceofcardiaccellstoncxknockoutamodelstudy AT kobayashit resistanceofcardiaccellstoncxknockoutamodelstudy AT matsuokas resistanceofcardiaccellstoncxknockoutamodelstudy AT nomaa resistanceofcardiaccellstoncxknockoutamodelstudy |