Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population.
PURPOSE: To investigate a possible association between uterine leiomyomas and catechol-O-methyltransferase (COMT) polymorphisms in a Japanese population. METHODS: We compared the allele frequencies and genotype distributions of the exon 4 NlaIII restriction site polymorphism (RSP), the P2 promoter H...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1797092707232907264 |
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| author | Morikawa, J Yoshida, S Kennedy, S Takemura, N Sugimoto, M Kitao, K Deguchi, M Ohara, N Maruo, T |
| author_facet | Morikawa, J Yoshida, S Kennedy, S Takemura, N Sugimoto, M Kitao, K Deguchi, M Ohara, N Maruo, T |
| author_sort | Morikawa, J |
| collection | OXFORD |
| description | PURPOSE: To investigate a possible association between uterine leiomyomas and catechol-O-methyltransferase (COMT) polymorphisms in a Japanese population. METHODS: We compared the allele frequencies and genotype distributions of the exon 4 NlaIII restriction site polymorphism (RSP), the P2 promoter HindIII RSP at -1217, and the exon 6 BglI RSP in the COMT gene in 250 leiomyoma cases and 182 controls using polymerase chain reaction-restriction fragment-length polymorphism analysis. RESULTS: No significant differences in allele frequencies and genotype distributions of the exon 4 NlaIII RSP, the P2 promoter HindIII RSP at -1217, and the exon 6 BglI RSP were found between uterine leiomyoma cases and controls. Moreover, no associations were noted between these three polymorphisms in COMT genes and leiomyoma size or a family history of uterine leiomyomas. CONCLUSION: COMT gene polymorphisms are unlikely to be associated with an increased risk of uterine leiomyomas in a Japanese population. |
| first_indexed | 2024-03-07T03:49:50Z |
| format | Journal article |
| id | oxford-uuid:c0da743c-10b9-4417-8b27-a7d227bdad08 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:49:50Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:c0da743c-10b9-4417-8b27-a7d227bdad082022-03-27T05:57:20ZAssociation study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c0da743c-10b9-4417-8b27-a7d227bdad08EnglishSymplectic Elements at Oxford2008Morikawa, JYoshida, SKennedy, STakemura, NSugimoto, MKitao, KDeguchi, MOhara, NMaruo, TPURPOSE: To investigate a possible association between uterine leiomyomas and catechol-O-methyltransferase (COMT) polymorphisms in a Japanese population. METHODS: We compared the allele frequencies and genotype distributions of the exon 4 NlaIII restriction site polymorphism (RSP), the P2 promoter HindIII RSP at -1217, and the exon 6 BglI RSP in the COMT gene in 250 leiomyoma cases and 182 controls using polymerase chain reaction-restriction fragment-length polymorphism analysis. RESULTS: No significant differences in allele frequencies and genotype distributions of the exon 4 NlaIII RSP, the P2 promoter HindIII RSP at -1217, and the exon 6 BglI RSP were found between uterine leiomyoma cases and controls. Moreover, no associations were noted between these three polymorphisms in COMT genes and leiomyoma size or a family history of uterine leiomyomas. CONCLUSION: COMT gene polymorphisms are unlikely to be associated with an increased risk of uterine leiomyomas in a Japanese population. |
| spellingShingle | Morikawa, J Yoshida, S Kennedy, S Takemura, N Sugimoto, M Kitao, K Deguchi, M Ohara, N Maruo, T Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population. |
| title | Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population. |
| title_full | Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population. |
| title_fullStr | Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population. |
| title_full_unstemmed | Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population. |
| title_short | Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population. |
| title_sort | association study between catechol o methyltransferase polymorphisms and uterine leiomyomas in a japanese population |
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