OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection.
OX40, a member of the TNF receptor superfamily, is expressed on activated T cells and implicated in stimulation of T cells and T-dependent humoral responses. We generated OX40-/- mice and found that the formation of extrafollicular plasma cells, germinal centers, and antibody responses was independe...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1826294710808870912 |
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| author | Kopf, M Ruedl, C Schmitz, N Gallimore, A Lefrang, K Ecabert, B Odermatt, B Bachmann, M |
| author_facet | Kopf, M Ruedl, C Schmitz, N Gallimore, A Lefrang, K Ecabert, B Odermatt, B Bachmann, M |
| author_sort | Kopf, M |
| collection | OXFORD |
| description | OX40, a member of the TNF receptor superfamily, is expressed on activated T cells and implicated in stimulation of T cells and T-dependent humoral responses. We generated OX40-/- mice and found that the formation of extrafollicular plasma cells, germinal centers, and antibody responses was independent of OX40. After infection with LCMV and influenza virus, OX40-/- mice retain primary and memory cytotoxic T cell responses with normal expansion and decline of specific CTL. In contrast, CD4+ T cell proliferation and the number of IFN-gamma-producing CD4+ T cells were reduced in OX40-/- mice. Moreover, the number of CD4+ T cells infiltrating the lungs of influenza virus-infected OX40-/- mice was reduced. These results define a unique role of OX40 in the generation of optimal CD4+ T cell responses in vivo. |
| first_indexed | 2024-03-07T03:49:53Z |
| format | Journal article |
| id | oxford-uuid:c0dd1237-7e7d-4aa2-bbd8-8b9e3e6005c9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:49:53Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:c0dd1237-7e7d-4aa2-bbd8-8b9e3e6005c92022-03-27T05:57:24ZOX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c0dd1237-7e7d-4aa2-bbd8-8b9e3e6005c9EnglishSymplectic Elements at Oxford1999Kopf, MRuedl, CSchmitz, NGallimore, ALefrang, KEcabert, BOdermatt, BBachmann, MOX40, a member of the TNF receptor superfamily, is expressed on activated T cells and implicated in stimulation of T cells and T-dependent humoral responses. We generated OX40-/- mice and found that the formation of extrafollicular plasma cells, germinal centers, and antibody responses was independent of OX40. After infection with LCMV and influenza virus, OX40-/- mice retain primary and memory cytotoxic T cell responses with normal expansion and decline of specific CTL. In contrast, CD4+ T cell proliferation and the number of IFN-gamma-producing CD4+ T cells were reduced in OX40-/- mice. Moreover, the number of CD4+ T cells infiltrating the lungs of influenza virus-infected OX40-/- mice was reduced. These results define a unique role of OX40 in the generation of optimal CD4+ T cell responses in vivo. |
| spellingShingle | Kopf, M Ruedl, C Schmitz, N Gallimore, A Lefrang, K Ecabert, B Odermatt, B Bachmann, M OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. |
| title | OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. |
| title_full | OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. |
| title_fullStr | OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. |
| title_full_unstemmed | OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. |
| title_short | OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. |
| title_sort | ox40 deficient mice are defective in th cell proliferation but are competent in generating b cell and ctl responses after virus infection |
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