Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation processes change during cancer evolution due to the lack of reliabl...

Celý popis

Podrobná bibliografie
Hlavní autoři: Rubanova, Y, Shi, R, Harrigan, CF, Li, R, Wintersinger, J, Sahin, N, Deshwar, A, PCAWG Evolution and Heterogeneity Working Group, Morris, Q, PCAWG Consortium
Další autoři: Wedge, DC
Médium: Journal article
Jazyk:English
Vydáno: Springer Nature 2020