Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

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The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation processes change during cancer evolution due to the lack of reliabl...

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Библиографические подробности
Главные авторы:	Rubanova, Y, Shi, R, Harrigan, CF, Li, R, Wintersinger, J, Sahin, N, Deshwar, A, PCAWG Evolution and Heterogeneity Working Group, Morris, Q, PCAWG Consortium
Другие авторы:	Wedge, DC
Формат:	Journal article
Язык:	English
Опубликовано:	Springer Nature 2020

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