Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients.
BACKGROUND: The relationship between chromosome 18q allelic imbalance (AI) and survival in colorectal cancer (CRC) is unclear, and study design may have contributed to inconsistent results previously reported. PATIENTS AND METHODS: Two hundred and eighty tumours from CRC patients participating in a...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1826294750087479296 |
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| author | Popat, S Zhao, D Chen, Z Pan, H Shao, Y Chandler, I Houlston, R |
| author_facet | Popat, S Zhao, D Chen, Z Pan, H Shao, Y Chandler, I Houlston, R |
| author_sort | Popat, S |
| collection | OXFORD |
| description | BACKGROUND: The relationship between chromosome 18q allelic imbalance (AI) and survival in colorectal cancer (CRC) is unclear, and study design may have contributed to inconsistent results previously reported. PATIENTS AND METHODS: Two hundred and eighty tumours from CRC patients participating in a molecular sub-study from a single multicentre trial of adjuvant intra-portal 5-fluorouracil were genotyped at 5 chromosome 18q microsatellite markers, blinded to clinical data and prospective to follow-up. The relationship between overall survival and AI was examined. RESULTS: Two hundred and fifty-five tumours were informative for AI. The overall rate of AI was 49%. AI was not associated with age, tumour site or size. There was no difference in five-year survival rate between patients with (60.0% SE 5.2%) and without AI (61.4% SE 5.0%), even after correcting for covariates (HR=1.17, 95%CI:0.79-1.74, p=0.4). CONCLUSION: Our data does not [corrected] support chromosome 18q AI as an important marker of survival in the adjuvant setting. It should not, therefore, be used outside clinical trials. |
| first_indexed | 2024-03-07T03:50:29Z |
| format | Journal article |
| id | oxford-uuid:c115f8df-7d00-4189-814d-923d2ba25853 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:50:29Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:c115f8df-7d00-4189-814d-923d2ba258532022-03-27T05:58:56ZRelationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c115f8df-7d00-4189-814d-923d2ba25853EnglishSymplectic Elements at Oxford2007Popat, SZhao, DChen, ZPan, HShao, YChandler, IHoulston, R BACKGROUND: The relationship between chromosome 18q allelic imbalance (AI) and survival in colorectal cancer (CRC) is unclear, and study design may have contributed to inconsistent results previously reported. PATIENTS AND METHODS: Two hundred and eighty tumours from CRC patients participating in a molecular sub-study from a single multicentre trial of adjuvant intra-portal 5-fluorouracil were genotyped at 5 chromosome 18q microsatellite markers, blinded to clinical data and prospective to follow-up. The relationship between overall survival and AI was examined. RESULTS: Two hundred and fifty-five tumours were informative for AI. The overall rate of AI was 49%. AI was not associated with age, tumour site or size. There was no difference in five-year survival rate between patients with (60.0% SE 5.2%) and without AI (61.4% SE 5.0%), even after correcting for covariates (HR=1.17, 95%CI:0.79-1.74, p=0.4). CONCLUSION: Our data does not [corrected] support chromosome 18q AI as an important marker of survival in the adjuvant setting. It should not, therefore, be used outside clinical trials. |
| spellingShingle | Popat, S Zhao, D Chen, Z Pan, H Shao, Y Chandler, I Houlston, R Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients. |
| title | Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients. |
| title_full | Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients. |
| title_fullStr | Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients. |
| title_full_unstemmed | Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients. |
| title_short | Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients. |
| title_sort | relationship between chromosome 18q status and colorectal cancer prognosis a prospective blinded analysis of 280 patients |
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