Basal normoglycemia attained with chlorpropamide in mild diabetes.

Sixteen adult-onset diabetics, who were thought by current criteria to be well controlled on diet alone, had substantially elevated overnight, basal plasma glucose concentrations. Chlorpropamide had a sufficiently prolonged stimulatory effect on the beta cells such that normal basal plasma glucose l...

ver descrição completa

Detalhes bibliográficos
Main Authors: Holman, R, Turner, R
Formato: Journal article
Idioma:English
Publicado em: 1978
_version_ 1826294782824022016
author Holman, R
Turner, R
author_facet Holman, R
Turner, R
author_sort Holman, R
collection OXFORD
description Sixteen adult-onset diabetics, who were thought by current criteria to be well controlled on diet alone, had substantially elevated overnight, basal plasma glucose concentrations. Chlorpropamide had a sufficiently prolonged stimulatory effect on the beta cells such that normal basal plasma glucose levels were obtained in 13 patients. Both basal plasma C-peptide levels and the C-peptide response to meals became normal, with improved postprandial glycemia. Diurnal plasma triglyceride levels were reduced. Plasma growth hormone levels were normal both before and after therapy. When diet alone is insufficient to maintain basal normoglycemia in mild diabetes, chlorporpamide is as effective as basal insulin supplements in producing normal basal plasma glucose levels.
first_indexed 2024-03-07T03:50:59Z
format Journal article
id oxford-uuid:c13f1125-3fe4-4c3d-b022-b6fb8849c38c
institution University of Oxford
language English
last_indexed 2024-03-07T03:50:59Z
publishDate 1978
record_format dspace
spelling oxford-uuid:c13f1125-3fe4-4c3d-b022-b6fb8849c38c2022-03-27T06:00:06ZBasal normoglycemia attained with chlorpropamide in mild diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c13f1125-3fe4-4c3d-b022-b6fb8849c38cEnglishSymplectic Elements at Oxford1978Holman, RTurner, RSixteen adult-onset diabetics, who were thought by current criteria to be well controlled on diet alone, had substantially elevated overnight, basal plasma glucose concentrations. Chlorpropamide had a sufficiently prolonged stimulatory effect on the beta cells such that normal basal plasma glucose levels were obtained in 13 patients. Both basal plasma C-peptide levels and the C-peptide response to meals became normal, with improved postprandial glycemia. Diurnal plasma triglyceride levels were reduced. Plasma growth hormone levels were normal both before and after therapy. When diet alone is insufficient to maintain basal normoglycemia in mild diabetes, chlorporpamide is as effective as basal insulin supplements in producing normal basal plasma glucose levels.
spellingShingle Holman, R
Turner, R
Basal normoglycemia attained with chlorpropamide in mild diabetes.
title Basal normoglycemia attained with chlorpropamide in mild diabetes.
title_full Basal normoglycemia attained with chlorpropamide in mild diabetes.
title_fullStr Basal normoglycemia attained with chlorpropamide in mild diabetes.
title_full_unstemmed Basal normoglycemia attained with chlorpropamide in mild diabetes.
title_short Basal normoglycemia attained with chlorpropamide in mild diabetes.
title_sort basal normoglycemia attained with chlorpropamide in mild diabetes
work_keys_str_mv AT holmanr basalnormoglycemiaattainedwithchlorpropamideinmilddiabetes
AT turnerr basalnormoglycemiaattainedwithchlorpropamideinmilddiabetes