High-resolution ion microscope imaging over wide mass ranges using electrodynamic post-extraction differential acceleration
A time-dependent postextraction differential acceleration (PEDA) potential was used to temporally focus increasingly heavy ions in a stigmatic imaging mass spectrometer, allowing them to be imaged with high mass and spatial resolutions over a broad mass-to-charge (m/z) range. By applying a linearly...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2020
|
| _version_ | 1797092837534203904 |
|---|---|
| author | Guo, A Burleigh, RJ Smith, N Brouard, M Burt, M |
| author_facet | Guo, A Burleigh, RJ Smith, N Brouard, M Burt, M |
| author_sort | Guo, A |
| collection | OXFORD |
| description | A time-dependent postextraction differential acceleration (PEDA) potential was used to temporally focus increasingly heavy ions in a stigmatic imaging mass spectrometer, allowing them to be imaged with high mass and spatial resolutions over a broad mass-to-charge (m/z) range. By applying a linearly rising potential to the ion extraction electrode, sequential m/z ratios were subjected to a changing electric field, allowing their foci to coincide at the detector. Using this approach, at least 75% of the maximum mass resolution was obtained over a 300–600 Da range when the ion microscope was focused around 450 Da, representing more than a 10-fold increase over the conventional single-field PEDA method. |
| first_indexed | 2024-03-07T03:51:45Z |
| format | Journal article |
| id | oxford-uuid:c1831d73-2f8d-4f5b-b137-6ab9f271d149 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:51:45Z |
| publishDate | 2020 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:c1831d73-2f8d-4f5b-b137-6ab9f271d1492022-03-27T06:02:07ZHigh-resolution ion microscope imaging over wide mass ranges using electrodynamic post-extraction differential accelerationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c1831d73-2f8d-4f5b-b137-6ab9f271d149EnglishSymplectic ElementsAmerican Chemical Society2020Guo, ABurleigh, RJSmith, NBrouard, MBurt, MA time-dependent postextraction differential acceleration (PEDA) potential was used to temporally focus increasingly heavy ions in a stigmatic imaging mass spectrometer, allowing them to be imaged with high mass and spatial resolutions over a broad mass-to-charge (m/z) range. By applying a linearly rising potential to the ion extraction electrode, sequential m/z ratios were subjected to a changing electric field, allowing their foci to coincide at the detector. Using this approach, at least 75% of the maximum mass resolution was obtained over a 300–600 Da range when the ion microscope was focused around 450 Da, representing more than a 10-fold increase over the conventional single-field PEDA method. |
| spellingShingle | Guo, A Burleigh, RJ Smith, N Brouard, M Burt, M High-resolution ion microscope imaging over wide mass ranges using electrodynamic post-extraction differential acceleration |
| title | High-resolution ion microscope imaging over wide mass ranges using electrodynamic post-extraction differential acceleration |
| title_full | High-resolution ion microscope imaging over wide mass ranges using electrodynamic post-extraction differential acceleration |
| title_fullStr | High-resolution ion microscope imaging over wide mass ranges using electrodynamic post-extraction differential acceleration |
| title_full_unstemmed | High-resolution ion microscope imaging over wide mass ranges using electrodynamic post-extraction differential acceleration |
| title_short | High-resolution ion microscope imaging over wide mass ranges using electrodynamic post-extraction differential acceleration |
| title_sort | high resolution ion microscope imaging over wide mass ranges using electrodynamic post extraction differential acceleration |
| work_keys_str_mv | AT guoa highresolutionionmicroscopeimagingoverwidemassrangesusingelectrodynamicpostextractiondifferentialacceleration AT burleighrj highresolutionionmicroscopeimagingoverwidemassrangesusingelectrodynamicpostextractiondifferentialacceleration AT smithn highresolutionionmicroscopeimagingoverwidemassrangesusingelectrodynamicpostextractiondifferentialacceleration AT brouardm highresolutionionmicroscopeimagingoverwidemassrangesusingelectrodynamicpostextractiondifferentialacceleration AT burtm highresolutionionmicroscopeimagingoverwidemassrangesusingelectrodynamicpostextractiondifferentialacceleration |