Coordination of T cell activation and migration through formation of the immunological synapse.
T cell activation is based on interactions of T cell antigen receptors with MHC-peptide complexes in a specialized cell-cell junction between the T cell and antigen-presenting cell-the immunological synapse. The immunological synapse coordinates naïve T cell activation and migration by stopping T ce...
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797092845296812032 |
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| author | Dustin, M |
| author_facet | Dustin, M |
| author_sort | Dustin, M |
| collection | OXFORD |
| description | T cell activation is based on interactions of T cell antigen receptors with MHC-peptide complexes in a specialized cell-cell junction between the T cell and antigen-presenting cell-the immunological synapse. The immunological synapse coordinates naïve T cell activation and migration by stopping T cell migration with antigen-presenting cells bearing appropriate major histocompatibility complex (MHC) peptide complexes. At the same time, the immunological synapse allows full T cell activation through sustained signaling over a period of several hours. The immunological synapse supports activation in the absence of continued T cell migration, which is required for T cell activation through serial encounters. Src and Syk family kinases are activated early in immunological synapse formation, but this signaling process returns to the basal level after 30 min; at the same time, the interactions between T cell receptors (TCRs) and MHC peptides are stabilized within the immunological synapse. The molecular pattern of the mature synapse in helper T cells is a self-stabilized structure that is correlated with cytokine production and proliferation. I propose that this molecular pattern and its specific biochemical constituents are necessary to amplify signals from the partially desensitized TCR. |
| first_indexed | 2024-03-07T03:51:52Z |
| format | Journal article |
| id | oxford-uuid:c18e2de2-c83b-43df-b424-b93c5322e8ee |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:51:52Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:c18e2de2-c83b-43df-b424-b93c5322e8ee2022-03-27T06:02:19ZCoordination of T cell activation and migration through formation of the immunological synapse.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c18e2de2-c83b-43df-b424-b93c5322e8eeEnglishSymplectic Elements at Oxford2003Dustin, MT cell activation is based on interactions of T cell antigen receptors with MHC-peptide complexes in a specialized cell-cell junction between the T cell and antigen-presenting cell-the immunological synapse. The immunological synapse coordinates naïve T cell activation and migration by stopping T cell migration with antigen-presenting cells bearing appropriate major histocompatibility complex (MHC) peptide complexes. At the same time, the immunological synapse allows full T cell activation through sustained signaling over a period of several hours. The immunological synapse supports activation in the absence of continued T cell migration, which is required for T cell activation through serial encounters. Src and Syk family kinases are activated early in immunological synapse formation, but this signaling process returns to the basal level after 30 min; at the same time, the interactions between T cell receptors (TCRs) and MHC peptides are stabilized within the immunological synapse. The molecular pattern of the mature synapse in helper T cells is a self-stabilized structure that is correlated with cytokine production and proliferation. I propose that this molecular pattern and its specific biochemical constituents are necessary to amplify signals from the partially desensitized TCR. |
| spellingShingle | Dustin, M Coordination of T cell activation and migration through formation of the immunological synapse. |
| title | Coordination of T cell activation and migration through formation of the immunological synapse. |
| title_full | Coordination of T cell activation and migration through formation of the immunological synapse. |
| title_fullStr | Coordination of T cell activation and migration through formation of the immunological synapse. |
| title_full_unstemmed | Coordination of T cell activation and migration through formation of the immunological synapse. |
| title_short | Coordination of T cell activation and migration through formation of the immunological synapse. |
| title_sort | coordination of t cell activation and migration through formation of the immunological synapse |
| work_keys_str_mv | AT dustinm coordinationoftcellactivationandmigrationthroughformationoftheimmunologicalsynapse |