GATA3 Mutations Found in Breast Cancers May Be Associated with Aberrant Nuclear Localization, Reduced Transactivation and Cell Invasiveness

Geahča maid

• GATA3 mutations found in breast cancers may be associated with aberrant nuclear localization, reduced transactivation and cell invasiveness.
  Dahkki: Gaynor, K, et al.
  Almmustuhtton: (2013)
• A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome.
  Dahkki: Gaynor, K, et al.
  Almmustuhtton: (2009)
• Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.
  Dahkki: Grigorieva, I, et al.
  Almmustuhtton: (2010)
• The role of the transcription factor GATA3 in calcium homeostasis and tumourigenesis
  Dahkki: Gaynor, K, et al.
  Almmustuhtton: (2011)
• GATA3 haplo-insufficiency causes human HDR syndrome.
  Dahkki: Van Esch, H, et al.
  Almmustuhtton: (2000)