Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression.
OBJECTIVE: The present study aimed to 1) assess facial expression recognition in subjects with a previous history of major depressive disorder relative to subjects with no history of depression and 2) characterize the effects of acute citalopram infusion on recognition performance for both groups....
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|
| _version_ | 1797092884736901120 |
|---|---|
| author | Bhagwagar, Z Cowen, P Goodwin, G Harmer, C |
| author_facet | Bhagwagar, Z Cowen, P Goodwin, G Harmer, C |
| author_sort | Bhagwagar, Z |
| collection | OXFORD |
| description | OBJECTIVE: The present study aimed to 1) assess facial expression recognition in subjects with a previous history of major depressive disorder relative to subjects with no history of depression and 2) characterize the effects of acute citalopram infusion on recognition performance for both groups. METHOD: Unmedicated euthymic women with a history of major depression and matched comparison subjects with no history of depression were given a facial expression recognition task following intravenous infusion of saline or citalopram (10 mg) in a double-blind, between-group design. RESULTS: Following saline infusion, subjects with a previous history of depression showed a selectively greater recognition of fear relative to the subjects with no history of depression. The abnormal fear processing observed in the subjects with a previous history of depression was normalized following citalopram infusion, an effect that was opposite to that seen with the subjects with no history of depression. CONCLUSIONS: These results suggest that increased recognition of fear is a trait vulnerability marker for depression and that this is normalized following a single dose of citalopram. |
| first_indexed | 2024-03-07T03:52:24Z |
| format | Journal article |
| id | oxford-uuid:c1b809d9-3cef-4c63-aeba-937c183670b3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:52:24Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:c1b809d9-3cef-4c63-aeba-937c183670b32022-03-27T06:03:38ZNormalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c1b809d9-3cef-4c63-aeba-937c183670b3EnglishSymplectic Elements at Oxford2004Bhagwagar, ZCowen, PGoodwin, GHarmer, C OBJECTIVE: The present study aimed to 1) assess facial expression recognition in subjects with a previous history of major depressive disorder relative to subjects with no history of depression and 2) characterize the effects of acute citalopram infusion on recognition performance for both groups. METHOD: Unmedicated euthymic women with a history of major depression and matched comparison subjects with no history of depression were given a facial expression recognition task following intravenous infusion of saline or citalopram (10 mg) in a double-blind, between-group design. RESULTS: Following saline infusion, subjects with a previous history of depression showed a selectively greater recognition of fear relative to the subjects with no history of depression. The abnormal fear processing observed in the subjects with a previous history of depression was normalized following citalopram infusion, an effect that was opposite to that seen with the subjects with no history of depression. CONCLUSIONS: These results suggest that increased recognition of fear is a trait vulnerability marker for depression and that this is normalized following a single dose of citalopram. |
| spellingShingle | Bhagwagar, Z Cowen, P Goodwin, G Harmer, C Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. |
| title | Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. |
| title_full | Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. |
| title_fullStr | Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. |
| title_full_unstemmed | Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. |
| title_short | Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. |
| title_sort | normalization of enhanced fear recognition by acute ssri treatment in subjects with a previous history of depression |
| work_keys_str_mv | AT bhagwagarz normalizationofenhancedfearrecognitionbyacutessritreatmentinsubjectswithaprevioushistoryofdepression AT cowenp normalizationofenhancedfearrecognitionbyacutessritreatmentinsubjectswithaprevioushistoryofdepression AT goodwing normalizationofenhancedfearrecognitionbyacutessritreatmentinsubjectswithaprevioushistoryofdepression AT harmerc normalizationofenhancedfearrecognitionbyacutessritreatmentinsubjectswithaprevioushistoryofdepression |