Ventral prefrontal cortex is not essential for working memory.
It is widely held that the prefrontal cortex is important for working memory. It has been suggested that the inferior convexity (IC) may play a special role in working memory for form and color (). We have therefore assessed the ability of monkeys with IC lesions to perform visual pattern associatio...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1997
|
| _version_ | 1797092902325714944 |
|---|---|
| author | Rushworth, M Nixon, P Eacott, M Passingham, R |
| author_facet | Rushworth, M Nixon, P Eacott, M Passingham, R |
| author_sort | Rushworth, M |
| collection | OXFORD |
| description | It is widely held that the prefrontal cortex is important for working memory. It has been suggested that the inferior convexity (IC) may play a special role in working memory for form and color (). We have therefore assessed the ability of monkeys with IC lesions to perform visual pattern association tasks and color-matching tasks, both with and without delay. In experiment 1, six monkeys were trained on a visual association task with delays of up to 2 sec. Conservative IC lesions that removed lateral area 47/12 in three animals had no effect on the task. Further experiments showed that these lesions had no effect on the postoperative new learning of a color-matching task with delays of up to 2 sec or versions of the visual association task involving delays of up to 8 sec. In experiment 2, larger lesions of both areas 47/12 and 45A were made in the three control animals. This lesion caused a profound deficit in the ability to relearn simultaneous color matching, but subsequent matching with delays of up to 8 sec was clearly unimpaired. We suggest that the IC may be more important for stimulus selection and attention as opposed to working memory. |
| first_indexed | 2024-03-07T03:52:39Z |
| format | Journal article |
| id | oxford-uuid:c1cee6e8-8422-4ec1-be64-8a07663dbdb2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:52:39Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:c1cee6e8-8422-4ec1-be64-8a07663dbdb22022-03-27T06:04:15ZVentral prefrontal cortex is not essential for working memory.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c1cee6e8-8422-4ec1-be64-8a07663dbdb2EnglishSymplectic Elements at Oxford1997Rushworth, MNixon, PEacott, MPassingham, RIt is widely held that the prefrontal cortex is important for working memory. It has been suggested that the inferior convexity (IC) may play a special role in working memory for form and color (). We have therefore assessed the ability of monkeys with IC lesions to perform visual pattern association tasks and color-matching tasks, both with and without delay. In experiment 1, six monkeys were trained on a visual association task with delays of up to 2 sec. Conservative IC lesions that removed lateral area 47/12 in three animals had no effect on the task. Further experiments showed that these lesions had no effect on the postoperative new learning of a color-matching task with delays of up to 2 sec or versions of the visual association task involving delays of up to 8 sec. In experiment 2, larger lesions of both areas 47/12 and 45A were made in the three control animals. This lesion caused a profound deficit in the ability to relearn simultaneous color matching, but subsequent matching with delays of up to 8 sec was clearly unimpaired. We suggest that the IC may be more important for stimulus selection and attention as opposed to working memory. |
| spellingShingle | Rushworth, M Nixon, P Eacott, M Passingham, R Ventral prefrontal cortex is not essential for working memory. |
| title | Ventral prefrontal cortex is not essential for working memory. |
| title_full | Ventral prefrontal cortex is not essential for working memory. |
| title_fullStr | Ventral prefrontal cortex is not essential for working memory. |
| title_full_unstemmed | Ventral prefrontal cortex is not essential for working memory. |
| title_short | Ventral prefrontal cortex is not essential for working memory. |
| title_sort | ventral prefrontal cortex is not essential for working memory |
| work_keys_str_mv | AT rushworthm ventralprefrontalcortexisnotessentialforworkingmemory AT nixonp ventralprefrontalcortexisnotessentialforworkingmemory AT eacottm ventralprefrontalcortexisnotessentialforworkingmemory AT passinghamr ventralprefrontalcortexisnotessentialforworkingmemory |