Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Epidemiological data show that reproductive and hormonal factors are involved in the etiology of endometrial cancer, but there is little data on the association with endogenous sex hormone levels. We analyzed the association between prediagnostic serum concentrations of sex steroids and endometrial...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2008
|
| _version_ | 1797092905191473152 |
|---|---|
| author | Allen, N Key, T Dossus, L Rinaldi, S Cust, A Lukanova, A Peeters, P Onland-Moret, N Lahmann, P Berrino, F Panico, S Larrañaga, N Pera, G Tormo, M Sánchez, M Ramón Quirós, J Ardanaz, E Tjønneland, A Olsen, A Chang-Claude, J Linseisen, J Schulz, M Boeing, H Lundin, E Palli, D |
| author_facet | Allen, N Key, T Dossus, L Rinaldi, S Cust, A Lukanova, A Peeters, P Onland-Moret, N Lahmann, P Berrino, F Panico, S Larrañaga, N Pera, G Tormo, M Sánchez, M Ramón Quirós, J Ardanaz, E Tjønneland, A Olsen, A Chang-Claude, J Linseisen, J Schulz, M Boeing, H Lundin, E Palli, D |
| author_sort | Allen, N |
| collection | OXFORD |
| description | Epidemiological data show that reproductive and hormonal factors are involved in the etiology of endometrial cancer, but there is little data on the association with endogenous sex hormone levels. We analyzed the association between prediagnostic serum concentrations of sex steroids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition using a nested case-control design of 247 incident endometrial cancer cases and 481 controls, matched on center, menopausal status, age, variables relating to blood collection, and, for premenopausal women, phase of menstrual cycle. Using conditional regression analysis, endometrial cancer risk among postmenopausal women was positively associated with increasing levels of total testosterone, free testosterone, estrone, total estradiol, and free estradiol. The odds ratios (ORs) for the highest versus lowest tertile were 2.66 (95% confidence interval (CI) 1.50-4.72; P=0.002 for a continuous linear trend) for estrone, 2.07 (95% CI 1.20-3.60; P=0.001) for estradiol, and 1.66 (95% CI 0.98-2.82; P=0.001) for free estradiol. For total and free testosterone, ORs for the highest versus lowest tertile were 1.44 (95% CI 0.88-2.36; P=0.05) and 2.05 (95% CI 1.23-3.42; P=0.005) respectively. Androstenedione and dehydroepiandrosterone sulfate were not associated with risk. Sex hormone-binding globulin was significantly inversely associated with risk (OR for the highest versus lowest tertile was 0.57, 95% CI 0.34-0.95; P=0.004). In premenopausal women, serum sex hormone concentrations were not clearly associated with endometrial cancer risk, but numbers were too small to draw firm conclusions. In conclusion, relatively high blood concentrations of estrogens and free testosterone are associated with an increased endometrial cancer risk in postmenopausal women. |
| first_indexed | 2024-03-07T03:52:42Z |
| format | Journal article |
| id | oxford-uuid:c1d2cdee-edab-4dd0-9634-f46ee0c8a5f6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:52:42Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:c1d2cdee-edab-4dd0-9634-f46ee0c8a5f62022-03-27T06:04:18ZEndogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c1d2cdee-edab-4dd0-9634-f46ee0c8a5f6EnglishSymplectic Elements at Oxford2008Allen, NKey, TDossus, LRinaldi, SCust, ALukanova, APeeters, POnland-Moret, NLahmann, PBerrino, FPanico, SLarrañaga, NPera, GTormo, MSánchez, MRamón Quirós, JArdanaz, ETjønneland, AOlsen, AChang-Claude, JLinseisen, JSchulz, MBoeing, HLundin, EPalli, DEpidemiological data show that reproductive and hormonal factors are involved in the etiology of endometrial cancer, but there is little data on the association with endogenous sex hormone levels. We analyzed the association between prediagnostic serum concentrations of sex steroids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition using a nested case-control design of 247 incident endometrial cancer cases and 481 controls, matched on center, menopausal status, age, variables relating to blood collection, and, for premenopausal women, phase of menstrual cycle. Using conditional regression analysis, endometrial cancer risk among postmenopausal women was positively associated with increasing levels of total testosterone, free testosterone, estrone, total estradiol, and free estradiol. The odds ratios (ORs) for the highest versus lowest tertile were 2.66 (95% confidence interval (CI) 1.50-4.72; P=0.002 for a continuous linear trend) for estrone, 2.07 (95% CI 1.20-3.60; P=0.001) for estradiol, and 1.66 (95% CI 0.98-2.82; P=0.001) for free estradiol. For total and free testosterone, ORs for the highest versus lowest tertile were 1.44 (95% CI 0.88-2.36; P=0.05) and 2.05 (95% CI 1.23-3.42; P=0.005) respectively. Androstenedione and dehydroepiandrosterone sulfate were not associated with risk. Sex hormone-binding globulin was significantly inversely associated with risk (OR for the highest versus lowest tertile was 0.57, 95% CI 0.34-0.95; P=0.004). In premenopausal women, serum sex hormone concentrations were not clearly associated with endometrial cancer risk, but numbers were too small to draw firm conclusions. In conclusion, relatively high blood concentrations of estrogens and free testosterone are associated with an increased endometrial cancer risk in postmenopausal women. |
| spellingShingle | Allen, N Key, T Dossus, L Rinaldi, S Cust, A Lukanova, A Peeters, P Onland-Moret, N Lahmann, P Berrino, F Panico, S Larrañaga, N Pera, G Tormo, M Sánchez, M Ramón Quirós, J Ardanaz, E Tjønneland, A Olsen, A Chang-Claude, J Linseisen, J Schulz, M Boeing, H Lundin, E Palli, D Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title | Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_full | Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_fullStr | Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_full_unstemmed | Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_short | Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_sort | endogenous sex hormones and endometrial cancer risk in women in the european prospective investigation into cancer and nutrition epic |
| work_keys_str_mv | AT allenn endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT keyt endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT dossusl endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT rinaldis endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT custa endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT lukanovaa endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT peetersp endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT onlandmoretn endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT lahmannp endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT berrinof endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT panicos endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT larranagan endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT perag endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT tormom endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT sanchezm endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT ramonquirosj endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT ardanaze endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT tjønnelanda endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT olsena endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT changclaudej endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT linseisenj endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT schulzm endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT boeingh endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT lundine endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic AT pallid endogenoussexhormonesandendometrialcancerriskinwomenintheeuropeanprospectiveinvestigationintocancerandnutritionepic |