ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.
The deubiquitylation enzyme USP7/HAUSP plays a major role in regulating genome stability and cancer prevention by controlling the key proteins involved in the DNA damage response. Despite this important role in controlling other proteins, USP7 itself has not been recognized as a target for regulatio...
Үндсэн зохиолчид: | Khoronenkova, S, Dianova, I, Ternette, N, Kessler, B, Parsons, J, Dianov, G |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
2012
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Ижил төстэй зүйлс
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ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage
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Regulation of USP7/HAUSP in response to DNA damage: yet another role for ATM.
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USP7/HAUSP stimulates repair of oxidative DNA lesions.
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USP7/HAUSP promotes the sequence-specific DNA binding activity of p53.
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Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress.
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