ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

Show other versions (1)

The deubiquitylation enzyme USP7/HAUSP plays a major role in regulating genome stability and cancer prevention by controlling the key proteins involved in the DNA damage response. Despite this important role in controlling other proteins, USP7 itself has not been recognized as a target for regulatio...

書目詳細資料
Main Authors:	Khoronenkova, S, Dianova, I, Ternette, N, Kessler, B, Parsons, J, Dianov, G
格式:	Journal article
語言:	English
出版:	2012

相似書籍

ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage
由: Khoronenkova, S, et al.
出版: (2012)

Regulation of USP7/HAUSP in response to DNA damage: yet another role for ATM.
由: Khoronenkova, S, et al.
出版: (2012)

USP7/HAUSP stimulates repair of oxidative DNA lesions.
由: Khoronenkova, S, et al.
出版: (2011)

USP7/HAUSP promotes the sequence-specific DNA binding activity of p53.
由: Feroz Sarkari, et al.
出版: (2010-09-01)

Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress.
由: Parsons, J, et al.
出版: (2012)

USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair.
由: Khoronenkova, S, et al.
出版: (2013)

Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.
由: Kessler, B, et al.
出版: (2007)

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.
由: Parsons, J, et al.
出版: (2011)

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.
由: Min Hu, et al.
出版: (2006-02-01)

ARF induction in response to DNA strand breaks is regulated by PARP1
由: Orlando, G, et al.
出版: (2013)

PE_PGRS38 Interaction With HAUSP Downregulates Antimycobacterial Host Defense via TRAF6
由: Jae-Sung Kim, et al.
出版: (2022-04-01)

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization
由: Stephanie J Papp, et al.
出版: (2015-03-01)

Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.
由: Jun Tang, et al.
出版: (2013-01-01)

CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.
由: Parsons, J, et al.
出版: (2008)

Correction: Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation
出版: (2013-01-01)

Correction: Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation.
由: Jun Tang, et al.
出版: (2013-01-01)

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.
由: Parsons, J, et al.
出版: (2009)

End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair.
由: Parsons, J, et al.
出版: (2005)

APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine.
由: Parsons, J, et al.
出版: (2005)

The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway
由: Konstantinos Karakostis, et al.
出版: (2024-01-01)

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM.
由: Enoch, T, et al.
出版: (1995)

DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.
由: Parsons, J, et al.
出版: (2005)

USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM
由: Ruiqiu Zhu, et al.
出版: (2024-11-01)

The emerging role of Mule and ARF in the regulation of base excision repair.
由: Khoronenkova, S, et al.
出版: (2011)

The emerging role of Mule and ARF in the regulation of base excision repair
由: Khoronenkova, S, et al.
出版: (2011)

Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy
由: Lianhui Sun, et al.
出版: (2025-02-01)

Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.
由: Meisenberg, C, et al.
出版: (2012)

Expression of Tp53 and USP7 during development of lungs in mouse model
由: Mushtaq Hussain, et al.
出版: (2020-12-01)

Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts.
由: Parsons, J, et al.
出版: (2005)

Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks.
由: Woodhouse, B, et al.
出版: (2008)

ATM and Chk2 kinase target the p53 cofactor Strap.
由: Adams, C, et al.
出版: (2008)

Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.
由: Alberto Valbuena, et al.
出版: (2011-02-01)

miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase.
由: Libing Song, et al.
出版: (2011-01-01)

APE1 is the major 3'-phosphoglycolate activity in human cell extracts.
由: Parsons, J, et al.
出版: (2004)

PPM1G promotes cell proliferation via modulating mutant GOF p53 protein expression in hepatocellular carcinoma
由: Wen Hu, et al.
出版: (2024-03-01)

Monitoring base excision repair proteins on damaged DNA using human cell extracts.
由: Parsons, J, et al.
出版: (2004)

USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF
由: Anamarija Jurisic, et al.
出版: (2024-04-01)

USP7 regulates growth and maintains the stemness of p53-mutant colorectal cancer cells via stabilizing of mutant p53
由: Xue Li, et al.
出版: (2024-09-01)

Phosphorylation of the DNA damage repair factor 53BP1 by ATM kinase controls neurodevelopmental programs in cortical brain organoids.
由: Bitna Lim, et al.
出版: (2024-09-01)

Effects of USP7 on radiation sensitivity through p53 pathway in laryngeal squamous cell carcinoma
由: Hao Niu, et al.
出版: (2022-08-01)