Changing epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010–2020)
Bloodstream infection (BSI) poses a global health problem, with diverse organisms and rising antimicrobial resistance (AMR). Here, we characterized trends in BSI prevalence, AMR, and antibiotic use at a Vietnamese infectious diseases hospital from 2010 to 2020. Among 108,303 cultured blood samples,...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature [academic journals on nature.com]
2024
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| _version_ | 1817931002271498240 |
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| author | Nguyen, HTT Chau, V Nguyen, PHL Du, HD Nguyen, LNP Le, TQN Huynh, PT Nguyen, TNT Tran, TND Voong, VP Ha, TT Nguyen, PNQ Baker, S Thwaites, G Rabaa, M Pham, DT |
| author_facet | Nguyen, HTT Chau, V Nguyen, PHL Du, HD Nguyen, LNP Le, TQN Huynh, PT Nguyen, TNT Tran, TND Voong, VP Ha, TT Nguyen, PNQ Baker, S Thwaites, G Rabaa, M Pham, DT |
| author_sort | Nguyen, HTT |
| collection | OXFORD |
| description | Bloodstream infection (BSI) poses a global health problem, with diverse organisms and rising antimicrobial resistance (AMR). Here, we characterized trends in BSI prevalence, AMR, and antibiotic use at a Vietnamese infectious diseases hospital from 2010 to 2020. Among 108,303 cultured blood samples, 8.8% were positive, yielding 7995 pathogens. Of 7553 BSI cases, 86.4% were community-acquired. BSI prevalence varied from 17 to 35 cases/1000 admissions/year, highest in HIV/hepatitis wards and patients >60. The in-hospital mortality or hospice discharge outcome was 21.3%. The top three pathogens, E. coli (24%), K. pneumoniae (8.7%) and S. aureus (8.5%) exhibited increasing prevalence and multidrug resistance. Pathogens like Cryptococcus neoformans (8.4%), Talaromyces marneffei (6.7%), and Salmonella enterica (6.5%) declined. E. coli and K. pneumoniae were prevalent in older adults with community-acquired BSIs. Antibiotic use reached 842.6 DOT/1000 PD and significantly reduced after an antibiotic control policy. Enhanced surveillance and antimicrobial stewardship are crucial for managing BSIs in Vietnam. |
| first_indexed | 2024-12-09T03:15:05Z |
| format | Journal article |
| id | oxford-uuid:c1f8278e-92fa-45ba-98d9-18fcd3febcf9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:15:05Z |
| publishDate | 2024 |
| publisher | Springer Nature [academic journals on nature.com] |
| record_format | dspace |
| spelling | oxford-uuid:c1f8278e-92fa-45ba-98d9-18fcd3febcf92024-10-16T20:11:10ZChanging epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010–2020)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c1f8278e-92fa-45ba-98d9-18fcd3febcf9EnglishJisc Publications RouterSpringer Nature [academic journals on nature.com]2024Nguyen, HTTChau, VNguyen, PHLDu, HDNguyen, LNPLe, TQNHuynh, PTNguyen, TNTTran, TNDVoong, VPHa, TTNguyen, PNQBaker, SThwaites, GRabaa, MPham, DTBloodstream infection (BSI) poses a global health problem, with diverse organisms and rising antimicrobial resistance (AMR). Here, we characterized trends in BSI prevalence, AMR, and antibiotic use at a Vietnamese infectious diseases hospital from 2010 to 2020. Among 108,303 cultured blood samples, 8.8% were positive, yielding 7995 pathogens. Of 7553 BSI cases, 86.4% were community-acquired. BSI prevalence varied from 17 to 35 cases/1000 admissions/year, highest in HIV/hepatitis wards and patients >60. The in-hospital mortality or hospice discharge outcome was 21.3%. The top three pathogens, E. coli (24%), K. pneumoniae (8.7%) and S. aureus (8.5%) exhibited increasing prevalence and multidrug resistance. Pathogens like Cryptococcus neoformans (8.4%), Talaromyces marneffei (6.7%), and Salmonella enterica (6.5%) declined. E. coli and K. pneumoniae were prevalent in older adults with community-acquired BSIs. Antibiotic use reached 842.6 DOT/1000 PD and significantly reduced after an antibiotic control policy. Enhanced surveillance and antimicrobial stewardship are crucial for managing BSIs in Vietnam. |
| spellingShingle | Nguyen, HTT Chau, V Nguyen, PHL Du, HD Nguyen, LNP Le, TQN Huynh, PT Nguyen, TNT Tran, TND Voong, VP Ha, TT Nguyen, PNQ Baker, S Thwaites, G Rabaa, M Pham, DT Changing epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010–2020) |
| title | Changing epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010–2020) |
| title_full | Changing epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010–2020) |
| title_fullStr | Changing epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010–2020) |
| title_full_unstemmed | Changing epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010–2020) |
| title_short | Changing epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010–2020) |
| title_sort | changing epidemiology and antimicrobial susceptibility of bloodstream infections at a vietnamese infectious diseases hospital 2010 2020 |
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