β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart.
Evidence suggests that β-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca(2+)-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2012
|
| _version_ | 1797092946225397760 |
|---|---|
| author | Lewis, A Aley, P Roomi, A Thomas, J Masgrau, R Garnham, C Shipman, K Paramore, C Bloor-Young, D Sanders, L Terrar, D Galione, A Churchill, G |
| author_facet | Lewis, A Aley, P Roomi, A Thomas, J Masgrau, R Garnham, C Shipman, K Paramore, C Bloor-Young, D Sanders, L Terrar, D Galione, A Churchill, G |
| author_sort | Lewis, A |
| collection | OXFORD |
| description | Evidence suggests that β-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca(2+)-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of these messengers requires direct measurements of their levels in response to receptor stimulation. Here we report that in intact Langendorff-perfused hearts β-adrenergic stimulation increased both messengers, with NAADP being transient and cADPR being sustained. Both NAADP and cADPR have physiological and therefore pathological relevance by providing alternative drug targets in the β-adrenergic receptor signaling pathway. |
| first_indexed | 2024-03-07T03:53:16Z |
| format | Journal article |
| id | oxford-uuid:c2009fb5-f3a2-42ed-acdc-22a49725fcff |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:53:16Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:c2009fb5-f3a2-42ed-acdc-22a49725fcff2022-03-27T06:05:44Zβ-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c2009fb5-f3a2-42ed-acdc-22a49725fcffEnglishSymplectic Elements at Oxford2012Lewis, AAley, PRoomi, AThomas, JMasgrau, RGarnham, CShipman, KParamore, CBloor-Young, DSanders, LTerrar, DGalione, AChurchill, GEvidence suggests that β-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca(2+)-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of these messengers requires direct measurements of their levels in response to receptor stimulation. Here we report that in intact Langendorff-perfused hearts β-adrenergic stimulation increased both messengers, with NAADP being transient and cADPR being sustained. Both NAADP and cADPR have physiological and therefore pathological relevance by providing alternative drug targets in the β-adrenergic receptor signaling pathway. |
| spellingShingle | Lewis, A Aley, P Roomi, A Thomas, J Masgrau, R Garnham, C Shipman, K Paramore, C Bloor-Young, D Sanders, L Terrar, D Galione, A Churchill, G β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart. |
| title | β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart. |
| title_full | β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart. |
| title_fullStr | β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart. |
| title_full_unstemmed | β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart. |
| title_short | β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart. |
| title_sort | β adrenergic receptor signaling increases naadp and cadpr levels in the heart |
| work_keys_str_mv | AT lewisa badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT aleyp badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT roomia badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT thomasj badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT masgraur badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT garnhamc badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT shipmank badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT paramorec badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT blooryoungd badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT sandersl badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT terrard badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT galionea badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart AT churchillg badrenergicreceptorsignalingincreasesnaadpandcadprlevelsintheheart |