Novel 2-oxoglutarate analogues modulate the epigenetic activity of the cancer-related human enzyme aspartate/asparagine-β-hydroxylase

Novel 2-oxoglutarate analogues modulate the epigenetic activity of the cancer-related human enzyme aspartate/asparagine-β-hydroxylase

Detalhes bibliográficos
Principais autores:	Brewitz, L, Tumber, A, Nakashima, Y, Schofield, CJ
Formato:	Conference item
Idioma:	English
Publicado em:	Wiley 2020

Registros relacionados

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
por: Brewitz, L, et al.
Publicado em: (2020)

Kinetic parameters of human aspartate/asparagine-β-hydroxylase suggest that it has a possible function in oxygen sensing
por: Brewitz, L, et al.
Publicado em: (2020)

Synthesis of novel pyridine-carboxylates as small-molecule inhibitors of human aspartate/asparagine-β-hydroxylase
por: Brewitz, L, et al.
Publicado em: (2020)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, L, et al.
Publicado em: (2020)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Lennart Brewitz, et al.
Publicado em: (2020-05-01)

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Lennart Brewitz, et al.
Publicado em: (2020-12-01)

Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylas
por: Brewitz, L, et al.
Publicado em: (2020)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
por: Pfeffer, I, et al.
Publicado em: (2019)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
por: Mole, D, et al.
Publicado em: (2003)

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
por: Mecinović, J, et al.
Publicado em: (2009)

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases
por: Brewitz, L, et al.
Publicado em: (2021)

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
por: Nakashima, Y, et al.
Publicado em: (2021)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
por: Inga Pfeffer, et al.
Publicado em: (2019-10-01)

Mechanistic and structural study of human aspartate/asparagine-beta-hydroxylase
por: Brasnett, A
Publicado em: (2023)

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
por: Yu Nakashima, et al.
Publicado em: (2021-11-01)

Human prolyl hydroxylase domain 2 reacts with O 2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes
por: Fiorini, G, et al.
Publicado em: (2024)

Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases.
por: Clifton, I, et al.
Publicado em: (2001)

Quantitative MS‐based proteomics: comparing the MCF‐7 cellular response to hypoxia and a 2‐oxoglutarate analogue
por: Bush, JT, et al.
Publicado em: (2020)

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.
por: Mantri, M, et al.
Publicado em: (2010)

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6.
por: Mantri, M, et al.
Publicado em: (2010)

Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes
por: Giorgia Fiorini, et al.
Publicado em: (2024-10-01)

Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia
por: Huang-Hui Liu, et al.
Publicado em: (2024-04-01)

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.
por: Schofield, C, et al.
Publicado em: (1999)

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
por: Abboud, M, et al.
Publicado em: (2018)

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
por: McNeill, L, et al.
Publicado em: (2002)

Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH
por: Krishnan, A, et al.
Publicado em: (2024)

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
por: Yang, M, et al.
Publicado em: (2011)

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
por: McNeill, L, et al.
Publicado em: (2005)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
por: Conejo-Garcia, A, et al.
Publicado em: (2010)

p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
por: Longfei Deng, et al.
Publicado em: (2020-04-01)

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions.
por: Jasmin F Sydow, et al.
Publicado em: (2014-01-01)

Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2
por: Liu, X, et al.
Publicado em: (2023)

Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase
por: Pfeffer, I
Publicado em: (2014)

Novel Approach to Overcome Defects of Cell-SELEX in Developing Aptamers against Aspartate β‑Hydroxylase
por: Hadi Bakhtiari, et al.
Publicado em: (2021-04-01)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
por: Figg, WD, et al.
Publicado em: (2023)

Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas
por: Lisa-Marie Sturla, et al.
Publicado em: (2016-12-01)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
por: Conejo-Garcia, A, et al.
Publicado em: (2010)

Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase.
por: Turnbull, J, et al.
Publicado em: (2004)

Carbonyl-carbonyl interactions stabilize the partially allowed Ramachandran conformations of asparagine and aspartic acid.
por: Deane, C, et al.
Publicado em: (1999)

2-oxoglutarate-dependent oxygenases
por: Islam, M, et al.
Publicado em: (2018)