Neuroimaging in amyotrophic lateral sclerosis.
The catastrophic system failure in amyotrophic lateral sclerosis is characterized by progressive neurodegeneration within the corticospinal tracts, brainstem nuclei and spinal cord anterior horns, with an extra-motor pathology that has overlap with frontotemporal dementia. The development of compute...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1826294941778706432 |
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| author | Turner, M Agosta, F Bede, P Govind, V Lulé, D Verstraete, E |
| author_facet | Turner, M Agosta, F Bede, P Govind, V Lulé, D Verstraete, E |
| author_sort | Turner, M |
| collection | OXFORD |
| description | The catastrophic system failure in amyotrophic lateral sclerosis is characterized by progressive neurodegeneration within the corticospinal tracts, brainstem nuclei and spinal cord anterior horns, with an extra-motor pathology that has overlap with frontotemporal dementia. The development of computed tomography and, even more so, MRI has brought insights into neurological disease, previously only available through post-mortem study. Although largely research-based, radionuclide imaging has continued to provide mechanistic insights into neurodegenerative disorders. The evolution of MRI to use advanced sequences highly sensitive to cortical and white matter structure, parenchymal metabolites and blood flow, many of which are now applicable to the spinal cord as well as the brain, make it a uniquely valuable tool for the study of a multisystem disorder such as amyotrophic lateral sclerosis. This comprehensive review considers the full range of neuroimaging techniques applied to amyotrophic lateral sclerosis over the last 25 years, the biomarkers they have revealed and future developments. |
| first_indexed | 2024-03-07T03:53:28Z |
| format | Journal article |
| id | oxford-uuid:c2115a8c-b07c-46cf-9f3e-39c6d21df33f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:53:28Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:c2115a8c-b07c-46cf-9f3e-39c6d21df33f2022-03-27T06:06:14ZNeuroimaging in amyotrophic lateral sclerosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c2115a8c-b07c-46cf-9f3e-39c6d21df33fEnglishSymplectic Elements at Oxford2012Turner, MAgosta, FBede, PGovind, VLulé, DVerstraete, EThe catastrophic system failure in amyotrophic lateral sclerosis is characterized by progressive neurodegeneration within the corticospinal tracts, brainstem nuclei and spinal cord anterior horns, with an extra-motor pathology that has overlap with frontotemporal dementia. The development of computed tomography and, even more so, MRI has brought insights into neurological disease, previously only available through post-mortem study. Although largely research-based, radionuclide imaging has continued to provide mechanistic insights into neurodegenerative disorders. The evolution of MRI to use advanced sequences highly sensitive to cortical and white matter structure, parenchymal metabolites and blood flow, many of which are now applicable to the spinal cord as well as the brain, make it a uniquely valuable tool for the study of a multisystem disorder such as amyotrophic lateral sclerosis. This comprehensive review considers the full range of neuroimaging techniques applied to amyotrophic lateral sclerosis over the last 25 years, the biomarkers they have revealed and future developments. |
| spellingShingle | Turner, M Agosta, F Bede, P Govind, V Lulé, D Verstraete, E Neuroimaging in amyotrophic lateral sclerosis. |
| title | Neuroimaging in amyotrophic lateral sclerosis. |
| title_full | Neuroimaging in amyotrophic lateral sclerosis. |
| title_fullStr | Neuroimaging in amyotrophic lateral sclerosis. |
| title_full_unstemmed | Neuroimaging in amyotrophic lateral sclerosis. |
| title_short | Neuroimaging in amyotrophic lateral sclerosis. |
| title_sort | neuroimaging in amyotrophic lateral sclerosis |
| work_keys_str_mv | AT turnerm neuroimaginginamyotrophiclateralsclerosis AT agostaf neuroimaginginamyotrophiclateralsclerosis AT bedep neuroimaginginamyotrophiclateralsclerosis AT govindv neuroimaginginamyotrophiclateralsclerosis AT luled neuroimaginginamyotrophiclateralsclerosis AT verstraetee neuroimaginginamyotrophiclateralsclerosis |