Clusters in an intrinsically disordered protein create a protein-binding site: the TolB-binding region of colicin E9.

Clusters in an intrinsically disordered protein create a protein-binding site: the TolB-binding region of colicin E9.

The 61-kDa colicin E9 protein toxin enters the cytoplasm of susceptible cells by interacting with outer membrane and periplasmic helper proteins and kills them by hydrolyzing their DNA. The membrane translocation function is located in the N-terminal domain of the colicin, with a key signal sequence...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Tozawa, K, Macdonald, C, Penfold, C, James, R, Kleanthous, K, Clayden, N, Moore, G
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2005

Antzeko izenburuak

Kinetic basis for the competitive recruitment of TolB by the intrinsically disordered translocation domain of colicin E9
nork: Papadakos, G, et al.
Argitaratua: (2012)

Kinetic basis for the competitive recruitment of TolB by the intrinsically disordered translocation domain of colicin E9.
nork: Papadakos, G, et al.
Argitaratua: (2012)

Characterisation of a mobile protein-binding epitope in the translocation domain of colicin E9.
nork: Macdonald, C, et al.
Argitaratua: (2004)

Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins.
nork: Bonsor, D, et al.
Argitaratua: (2009)

Competitive recruitment of the periplasmic translocation portal TolB by a natively disordered domain of colicin E9.
nork: Loftus, SR, et al.
Argitaratua: (2006)

Energy-dependent immunity protein release during tol-dependent nuclease colicin translocation.
nork: Vankemmelbeke, M, et al.
Argitaratua: (2009)

Thermodynamic consequences of bipartite immunity protein binding to the ribosomal ribonuclease colicin E3.
nork: Walker, D, et al.
Argitaratua: (2003)

The periplasmic protein TolB as a potential drug target in Pseudomonas aeruginosa.
nork: Alessandra Lo Sciuto, et al.
Argitaratua: (2014-01-01)

Directional porin binding of intrinsically disordered protein sequences promotes colicin epitope display in the bacterial periplasm
nork: Housden, NG, et al.
Argitaratua: (2018)

Flexibility in the receptor-binding domain of the enzymatic colicin E9 is required for toxicity against Escherichia coli cells.
nork: Penfold, C, et al.
Argitaratua: (2004)

Structure and mode of action of the TolA-TolB complex from Pseudomonas aeruginosa
nork: Holmes, P
Argitaratua: (2016)

Multistep binding of transition metals to the H-N-H endonuclease toxin colicin E9.
nork: Keeble, A, et al.
Argitaratua: (2002)

Nuclease colicins and their immunity proteins.
nork: Papadakos, G, et al.
Argitaratua: (2012)

Cell entry mechanism of enzymatic bacterial colicins: porin recruitment and the thermodynamics of receptor binding.
nork: Housden, N, et al.
Argitaratua: (2005)

Nano-functionalization and evaluation of antimicrobial activity of Tinospora cordifolia against the TolB protein of Pseudomonas aeruginosa – An antibacterial and computational study
nork: Himporna Nath, et al.
Argitaratua: (2023-04-01)

Destabilization of the colicin E9 Endonuclease domain by interaction with negatively charged phospholipids: implications for colicin translocation into bacteria.
nork: Mosbahi, K, et al.
Argitaratua: (2004)

The kinetic basis for dual recognition in colicin endonuclease-immunity protein complexes.
nork: Keeble, A, et al.
Argitaratua: (2005)

Calorimetric dissection of colicin DNase--immunity protein complex specificity.
nork: Keeble, A, et al.
Argitaratua: (2006)

OmpF enhances the ability of BtuB to protect susceptible Escherichia coli cells from colicin E9 cytotoxicity.
nork: Law, C, et al.
Argitaratua: (2003)

Xanthomonas citri subsp. citri requires a genus-specific outer membrane protein and TolB to coordinate cell membrane integrity and virulence
nork: Leilei Wu, et al.
Argitaratua: (2025-02-01)

Rapid detection of colicin E9-induced DNA damage using Escherichia coli cells carrying SOS promoter-lux fusions.
nork: Vankemmelbeke, M, et al.
Argitaratua: (2005)

Colicin E1 opens its hinge to plug TolC
nork: S Jimmy Budiardjo, et al.
Argitaratua: (2022-02-01)

Thermodynamic dissection of colicin interactions.
nork: Housden, N, et al.
Argitaratua: (2011)

Colicin biology.
nork: Cascales, E, et al.
Argitaratua: (2007)

Bifurcated binding of the OmpF receptor underpins import of the bacteriocin colicin N into Escherichia coli
nork: Jansen, KB, et al.
Argitaratua: (2020)

Colicin translocation across the Escherichia coli outer membrane.
nork: Housden, N, et al.
Argitaratua: (2012)

Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases.
nork: Keeble, A, et al.
Argitaratua: (2008)

Swimming against the tide: progress and challenges in our understanding of colicin translocation.
nork: Kleanthous, K
Argitaratua: (2010)

Highly discriminating protein-protein interaction specificities in the context of a conserved binding energy hotspot.
nork: Li, W, et al.
Argitaratua: (2004)

O-antigen dependent colicin insensitivity of uropathogenic Escherichia coli
nork: Sharp, C, et al.
Argitaratua: (2018)

The role of electrostatics in colicin nuclease domain translocation into bacterial cells.
nork: Walker, D, et al.
Argitaratua: (2007)

Global structural rearrangement of the cell penetrating ribonuclease colicin E3 on interaction with phospholipid membranes.
nork: Mosbahi, K, et al.
Argitaratua: (2006)

A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein
nork: Farrance, O, et al.
Argitaratua: (2013)

Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins
nork: Estella A. Newcombe, et al.
Argitaratua: (2021-08-01)

Identification of ligand binding sites in intrinsically disordered proteins with a differential binding score
nork: Qiao-Hong Chen, et al.
Argitaratua: (2021-11-01)

Colicins exploit native disorder to gain cell entry: a hitchhiker's guide to translocation.
nork: Bonsor, D, et al.
Argitaratua: (2008)

Identification of the catalytic motif of the microbial ribosome inactivating cytotoxin colicin E3.
nork: Walker, D, et al.
Argitaratua: (2004)

Colicins exploit native disorder to gain cell entry: A hitchhiker's guide to translocation
nork: Bonsor, D, et al.
Argitaratua: (2008)

Structure of the ultra-high-affinity colicin E2 DNase--Im2 complex.
nork: Wojdyla, J, et al.
Argitaratua: (2012)

Intrinsically disordered proteins: modes of binding with emphasis on disordered domains
nork: Owen Michael Morris, et al.
Argitaratua: (2021-10-01)