Four component meningococcal capsular Group B vaccine in preterm infants.
<p>The 4CMenB vaccine was introduced into the routine immunization schedule in the UK in September 2015 to protect against group B Neisseria meningitidis meningitis and septicemia. The vaccine is reactogenic in young infants, causing fever in 51-65% when co-administered with other vaccines [1,...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2017
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| _version_ | 1826294964424802304 |
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| author | Sadarangani, M Barlow, S Anthony, M Pollard, A |
| author_facet | Sadarangani, M Barlow, S Anthony, M Pollard, A |
| author_sort | Sadarangani, M |
| collection | OXFORD |
| description | <p>The 4CMenB vaccine was introduced into the routine immunization schedule in the UK in September 2015 to protect against group B Neisseria meningitidis meningitis and septicemia. The vaccine is reactogenic in young infants, causing fever in 51-65% when co-administered with other vaccines [1, 2]. This led to the unprecedented recommendation that all infants receive prophylactic paracetcmol (acetaminophen) with the vaccine. Preterm infants are immunized at the same chronological age and same schedule as term infants but have higher rates of post-immunization adverse events (AEs), particularly those infants born at <28 weeks gestation who are hospitalized in the neonatal unit when immunized [3]. Preterm babies were excluded from 4CMenB trials pre-licensure and no such trials have been registered (clinicaltrials.gov, 14th October 2016). Administration of a reactogenic vaccine in this population has led to heightened concern about AEs. This may impact on use of the vaccine in very preterm infants until they are discharged home, thus delaying protection of this vulnerable group against meningococcal disease.</p> |
| first_indexed | 2024-03-07T03:53:49Z |
| format | Journal article |
| id | oxford-uuid:c22bf4f0-105f-4d33-9795-3f34731f1638 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:53:49Z |
| publishDate | 2017 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:c22bf4f0-105f-4d33-9795-3f34731f16382022-03-27T06:07:01ZFour component meningococcal capsular Group B vaccine in preterm infants.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c22bf4f0-105f-4d33-9795-3f34731f1638EnglishSymplectic Elements at OxfordOxford University Press2017Sadarangani, MBarlow, SAnthony, MPollard, A<p>The 4CMenB vaccine was introduced into the routine immunization schedule in the UK in September 2015 to protect against group B Neisseria meningitidis meningitis and septicemia. The vaccine is reactogenic in young infants, causing fever in 51-65% when co-administered with other vaccines [1, 2]. This led to the unprecedented recommendation that all infants receive prophylactic paracetcmol (acetaminophen) with the vaccine. Preterm infants are immunized at the same chronological age and same schedule as term infants but have higher rates of post-immunization adverse events (AEs), particularly those infants born at <28 weeks gestation who are hospitalized in the neonatal unit when immunized [3]. Preterm babies were excluded from 4CMenB trials pre-licensure and no such trials have been registered (clinicaltrials.gov, 14th October 2016). Administration of a reactogenic vaccine in this population has led to heightened concern about AEs. This may impact on use of the vaccine in very preterm infants until they are discharged home, thus delaying protection of this vulnerable group against meningococcal disease.</p> |
| spellingShingle | Sadarangani, M Barlow, S Anthony, M Pollard, A Four component meningococcal capsular Group B vaccine in preterm infants. |
| title | Four component meningococcal capsular Group B vaccine in preterm infants. |
| title_full | Four component meningococcal capsular Group B vaccine in preterm infants. |
| title_fullStr | Four component meningococcal capsular Group B vaccine in preterm infants. |
| title_full_unstemmed | Four component meningococcal capsular Group B vaccine in preterm infants. |
| title_short | Four component meningococcal capsular Group B vaccine in preterm infants. |
| title_sort | four component meningococcal capsular group b vaccine in preterm infants |
| work_keys_str_mv | AT sadaranganim fourcomponentmeningococcalcapsulargroupbvaccineinpreterminfants AT barlows fourcomponentmeningococcalcapsulargroupbvaccineinpreterminfants AT anthonym fourcomponentmeningococcalcapsulargroupbvaccineinpreterminfants AT pollarda fourcomponentmeningococcalcapsulargroupbvaccineinpreterminfants |