Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production.
Degradation of cytosolic proteins depends largely on the proteasome, and a fraction of the cleavage products are presented as major histocompatibility complex (MHC) class I-bound ligands at the cell surface of antigen presenting cells. Proteolytic pathways accessory to the proteasome contribute to p...
Main Authors: | Kessler, B, Hong, X, Petrovic, J, Borodovsky, A, Dantuma, N, Bogyo, M, Overkleeft, H, Ploegh, H, Glas, R |
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Format: | Journal article |
Jezik: | English |
Izdano: |
2003
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