Targeting BRCA1 and BRCA2 deficiencies with G-quadruplex-interacting compounds

Targeting BRCA1 and BRCA2 deficiencies with G-quadruplex-interacting compounds

G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks. We have previously...

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Bibliographic Details
Main Authors:	Zimmer, J, Tacconi, E, Folio, C, Badie, S, Porru, M, Klare, K, Tumiati, M, Markkanen, E, Halder, S, Ryan, A, Jackson, S, Ramadan, K, Kuznetsov, S, Biroccio, A, Sale, J, Tarsounas, M
Format:	Journal article
Language:	English
Published:	Cell Press 2016

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