A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS (RCTS) OF EGFR-TARGETED MONOCLONAL ANTIBODY (MAB) THERAPY IN ADVANCED COLORECTAL CANCER (ACRC): IMPACT OF K-RAS STATUS

A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS (RCTS) OF EGFR-TARGETED MONOCLONAL ANTIBODY (MAB) THERAPY IN ADVANCED COLORECTAL CANCER (ACRC): IMPACT OF K-RAS STATUS

Dettagli Bibliografici
Autori principali:	Vale, C, Tierney, J, Meade, A, Fisher, D, Kaplan, R, Adams, R, Maughan, T, Parmar, M
Natura:	Journal article
Pubblicazione:	2009

Documenti analoghi

Impact of K-ras status on the effects of EGFR-targeted monoclonal antibody (MAb) therapy in advanced colorectal cancer (ACRC): A systematic review and meta-analysis of randomized controlled trials (RCTs)
di: Vale, C, et al.
Pubblicazione: (2009)

THROMBOCYTOSIS AS A PREDICTIVE AND PROGNOSTIC MARKER IN ADVANCED COLORECTAL CANCER (ACRC): RESULTS OF THE MRC COIN TRIAL EXPLORED
di: Maughan, T, et al.
Pubblicazione: (2010)

Addition of cetuximab to oxaliplatin-based combination chemotherapy (CT) in patients with KRAS wild-type advanced colorectal cancer (ACRC): a randomised superiority trial (MRC COIN)
di: Maughan, T, et al.
Pubblicazione: (2009)

Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis.
di: Vale, C, et al.
Pubblicazione: (2012)

Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis
di: Vale, C, et al.
Pubblicazione: (2012)

ADDITION OF CETUXIMAB TO OXALIPLATIN-BASED COMBINATION CHEMOTHERAPY (CT) IN PATIENTS WITH K-ras WILD-TYPE ADVANCED COLORECTAL CANCER (ACRC): EFFECTS ON OVERALL SURVIVAL. MRC COIN (CR10) TRIAL RESULTS
di: Adams, R, et al.
Pubblicazione: (2009)

Intermittent Chemotherapy (CT) Plus Continuous or Intermittent Cetuximab (C) in the First-line Treatment of Advanced Colorectal Cancer (aCRC): Results of the Two-arm Phase II Randomised MRC COIN-B Trial
di: Wasan, H, et al.
Pubblicazione: (2011)

HIGH THROUGHPUT SOMATIC PROFILING OF THE RAS-RAF-MAP AND PI3K-PTEN-AKT PATHWAYS IN ADVANCED COLORECTAL CANCER AND CORRELATIONS WITH RESPONSE TO CETUXIMAB
di: Smith, C, et al.
Pubblicazione: (2010)

FOCUS4-D: Results from a randomised, placebo controlled trial (RCT) of AZD8931 (an inhibitor of signalling by HER1, 2, and 3) in patients (pts) with advanced or metastatic colorectal cancer (aCRC) in tumours that are wildtype (wt) for BRAF, PIK3CA, KRAS and NRAS
di: Adams, R, et al.
Pubblicazione: (2016)

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer
di: Beth O. Van Emburgh, et al.
Pubblicazione: (2016-12-01)

Intermittent versus continuous oxaliplatin-based combination chemotherapy in patients with advanced colorectal cancer: a randomised non-inferiority trial (MRC COIN)
di: Adams, R, et al.
Pubblicazione: (2009)

Design and development of information portal for Asian Communication Resource Centre (ACRC).
di: Yohanes Ramli.
Pubblicazione: (2008)

Limited Efficacy of Anti-EGFR Monoclonal Antibodies in Colorectal Cancer Patients with Rare RAS Variants: Analysis of the C-CAT Database
di: Shuhei Suzuki, et al.
Pubblicazione: (2024-12-01)

Derived neutrophil to lymphocyte ratio as a prognostic factor in patients with advanced colorectal cancer according to RAS and BRAF status: a post-hoc analysis of the MRC COIN study.
di: Wood, G, et al.
Pubblicazione: (2017)

Chemotherapy-free intervals for patients with metastatic colorectal cancer remain an option.
di: Maughan, T, et al.
Pubblicazione: (2010)

Prognostic and predictive biomarkers for anti-EGFR monoclonal antibody therapy in RAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis
di: Xiaona Lu, et al.
Pubblicazione: (2023-11-01)

CYTOPLASMIC-MEMBRANE EGFR PREDICTS EXPANDED RAS MUTATION STATUS IN COLORECTAL CARCINOMAS?
di: Thiago David Alves PINTO, et al.
Pubblicazione: (2021-06-01)

Intra-tumoral Heterogeneity of KRAS and BRAF Mutation Status in Patients with Advanced Colorectal Cancer (aCRC) and Cost-Effectiveness of Multiple Sample Testing
di: Susan D. Richman, et al.
Pubblicazione: (2011-01-01)

Optimizing sequential treatment with anti-EGFR and VEGF mAb in metastatic colorectal cancer: current results and controversies
di: Chen DT, et al.
Pubblicazione: (2019-02-01)

A phase I study of Tc-99m-h-R3 monoclonal antibody (DiaCIM (R)), a humanized monoclonal antibody (mAB) for imaging EGFR-positive malignancies.
di: Reilly, R, et al.
Pubblicazione: (2002)

HUMANIZED MONOCLONAL-ANTIBODY (MAB) THERAPY FOR WEGENERS GRANULOMATOSIS (WG)
di: Lockwood, C, et al.
Pubblicazione: (1995)

Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2–3 randomised trial
di: Adams, R, et al.
Pubblicazione: (2017)

EGFR FISH analysis in colorectal cancer as a tool in selecting patients for antiEGFR monoclonal antibodies therapy
di: Mauro Moroni, et al.
Pubblicazione: (2011-12-01)

IMGT/mAb-KG: the knowledge graph for therapeutic monoclonal antibodies
di: Gaoussou Sanou, et al.
Pubblicazione: (2024-06-01)

Oxaliplatin/capecitabine vs oxaliplatin/infusional 5-FU in advanced colorectal cancer: the MRC COIN trial.
di: Madi, A, et al.
Pubblicazione: (2012)

Oxaliplatin/capecitabine vs oxaliplatin/infusional 5-FU in advanced colorectal cancer: The MRC COIN trial
di: Madi, A, et al.
Pubblicazione: (2012)

INTERMITTENT VS. CONTINUOUS OXALIPLATIN-FLUOROPYRIMIDINE CHEMOTHERAPY IN THE MRC COIN TRIAL IN ADVANCED COLORECTAL CANCER: UPDATED EFFICACY RESULTS, QUALITY OF LIFE AND POTENTIAL PREDICTIVE FACTORS
di: Adams, R, et al.
Pubblicazione: (2010)

Multispecificity of a recombinant anti-ras monoclonal antibody
di: Schrader, John W., et al.
Pubblicazione: (2017)

THE ADDITION OF CETUXIMAB TO OXALIPLATIN-FLUOROPYRIMIDINE CHEMOTHERAPY IN FIRST-LINE ADVANCED COLORECTAL CANCER IN THE MRC COIN TRIAL: IDENTIFICATION OF POTENTIALLY RESPONSIVE SUBSETS OF PATIENTS
di: Maughan, T, et al.
Pubblicazione: (2010)

Essay 4. What kinds of efficacies evade randomised controlled trials (RCTs)?
di: Alford, M
Pubblicazione: (2017)

Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras
di: Samantha I. Liang, et al.
Pubblicazione: (2018-03-01)

Mechanisms of action of monoclonal antibodies in oncology integrated in IMGT/mAb-DB
di: Taciana Manso, et al.
Pubblicazione: (2023-05-01)

Radiolabeling and biodistribution of monoclonal antibody (MAb) anti-CD20 with iodine-131
di: Akinkunmi Ganiyu Akanji, et al.
Pubblicazione: (2005-10-01)

Cetuximab therapy in first-line metastatic colorectal cancer and intermittent palliative chemotherapy: review of the COIN trial.
di: Adams, R, et al.
Pubblicazione: (2008)

A NOVEL COLORECTAL CANCER SUSCEPTIBILITY SNP IN THE EIF3H PROMOTER INFLUENCES PATIENT SURVIVAL AND RESPONSE TO TREATMENT
di: Cheadle, J, et al.
Pubblicazione: (2010)

Development of a framework to improve the process of recruitment to randomised controlled trials (RCTs): the SEAR (Screened, Eligible, Approached, Randomised) framework
di: Wilson, C, et al.
Pubblicazione: (2018)

Epitope mapping of an anti-diacylglycerol kinase delta monoclonal antibody DdMab-1
di: Masato Sano, et al.
Pubblicazione: (2020-12-01)

Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial.
di: Adams, R, et al.
Pubblicazione: (2011)

The use of healthcare systems data for RCTs
di: Alice-Maria Toader, et al.
Pubblicazione: (2024-01-01)

<it>EGFR</it> gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: a meta-analysis
di: Yang Zu-Yao, et al.
Pubblicazione: (2012-08-01)