Alternative base pairs attenuate influenza A virus when introduced into the duplex region of the conserved viral RNA promoter of either the NS or the PA gene.

Alternative base pairs attenuate influenza A virus when introduced into the duplex region of the conserved viral RNA promoter of either the NS or the PA gene.

The development of plasmid-based rescue systems for influenza virus has allowed previous studies of the neuraminidase (NA) virion RNA (vRNA) promoter to be extended, in order to test the hypothesis that alternative base pairs in the conserved influenza virus vRNA promoter cause attenuation when intr...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Catchpole, A, Mingay, L, Fodor, E, Brownlee, G
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2003

Những quyển sách tương tự

A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs.
Bằng: Fodor, E, et al.
Được phát hành: (2003)

Mutational analysis of the PA and PB2 subunits of the influenza RNA polymerase complex leads to new insights into function
Bằng: Fodor, E, et al.
Được phát hành: (2004)

A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.
Bằng: Fodor, E, et al.
Được phát hành: (2002)

Transcription of influenza A virus genes
Bằng: Fodor, E, et al.
Được phát hành: (2001)

Splicing of influenza A virus NS1 mRNA is independent of the viral NS1 protein.
Bằng: Robb, N, et al.
Được phát hành: (2010)

Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding.
Bằng: Fechter, P, et al.
Được phát hành: (2003)

The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes.
Bằng: Robb, N, et al.
Được phát hành: (2011)

The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes
Bằng: Robb, N, et al.
Được phát hành: (2011)

Attenuation of influenza A virus mRNA levels by promoter mutations.
Bằng: Fodor, E, et al.
Được phát hành: (1998)

Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins
Bằng: Aitor Nogales, et al.
Được phát hành: (2018-12-01)

In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complex.
Bằng: Deng, T, et al.
Được phát hành: (2005)

The surface-exposed PA51-72-loop of the influenza A virus polymerase is required for viral genome replication
Bằng: Nilsson-Payant, B, et al.
Được phát hành: (2018)

Reduced levels of neuraminidase of influenza A viruses correlate with attenuated phenotypes in mice.
Bằng: Solorzano, A, et al.
Được phát hành: (2000)

Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity.
Bằng: Chutikarn Chaimayo, et al.
Được phát hành: (2018-11-01)

Messenger RNAs that are not synthesized by RNA polymerase II can be 3' end cleaved and polyadenylated.
Bằng: Fodor, E, et al.
Được phát hành: (2000)

Generation of candidate H5N1 and H9N2 influenza vaccines for pandemic preparedness
Bằng: Subbarao, K, et al.
Được phát hành: (2001)

The applications of live attenuated influenza a virus with modified NS1 gene
Bằng: Hongbo Zhang, et al.
Được phát hành: (2025-03-01)

Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines
Bằng: Pui Wang, et al.
Được phát hành: (2019-10-01)

The predicted antigenicity of the haemagglutinin of the 1918 Spanish influenza pandemic suggests an avian origin.
Bằng: Brownlee, G, et al.
Được phát hành: (2001)

The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein
Bằng: Robb, N, et al.
Được phát hành: (2012)

The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein.
Bằng: Robb, N, et al.
Được phát hành: (2012)

The influenza virus panhandle is involved in the initiation of transcription.
Bằng: Fodor, E, et al.
Được phát hành: (1994)

NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome
Bằng: Robb, N, et al.
Được phát hành: (2009)

NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome.
Bằng: Robb, N, et al.
Được phát hành: (2009)

A Live Attenuated H9N2 Avian Influenza Vaccine Prevents the Viral Reassortment by Exchanging the HA and NS1 Packaging Signals
Bằng: Sujuan Chen, et al.
Được phát hành: (2021-02-01)

NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response.
Bằng: Wang, Z, et al.
Được phát hành: (2010)

NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response
Bằng: Wang, Z, et al.
Được phát hành: (2010)

Live attenuated influenza A virus vaccines with modified NS1 proteins for veterinary use
Bằng: Aitor Nogales, et al.
Được phát hành: (2022-07-01)

The RNA polymerase of influenza a virus is stabilized by interaction with its viral RNA promoter.
Bằng: Brownlee, G, et al.
Được phát hành: (2002)

The ''RNA-fork'' model for the initiation of influenza transcription
Bằng: Fodor, E, et al.
Được phát hành: (1996)

Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding.
Bằng: Maier, H, et al.
Được phát hành: (2008)

Characterization of the RNA-fork model of virion RNA in the initiation of transcription in influenza A virus.
Bằng: Fodor, E, et al.
Được phát hành: (1995)

Polyuridylated mRNA synthesized by a recombinant influenza virus is defective in nuclear export.
Bằng: Poon, L, et al.
Được phát hành: (2000)

Influenza virion-derived viral ribonucleoproteins synthesize both mRNA and cRNA in vitro.
Bằng: Vreede, F, et al.
Được phát hành: (2007)

The RNA polymerase of influenza a virus: mechanisms of viral transcription and replication.
Bằng: Fodor, E
Được phát hành: (2013)

Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics.
Bằng: Subbarao, K, et al.
Được phát hành: (2003)

Syntax of either in either… or… sentences
Bằng: Wu, Danfeng
Được phát hành: (2022)

An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA
Bằng: Jianyuan Zhao, et al.
Được phát hành: (2022-04-01)

Moving on out: transport and packaging of influenza viral RNA into virions
Bằng: Fodor, E, et al.
Được phát hành: (2016)

The glycosylation deficiency of flavivirus NS1 attenuates virus replication through interfering with the formation of viral replication compartments
Bằng: Shuhan Huang, et al.
Được phát hành: (2024-06-01)