Physiological and therapeutic differences between vitamin D, its metabolites and analogues
Since several metabolites and analogues of vitamin D have become available, their physiological and therapeutic potential have been studied in various disorders of mineral metabolism, particularly those classically termed vitamin D resistant. In some instances this resistance appears to be due to de...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Published: |
1977
|
| _version_ | 1797093029373280256 |
|---|---|
| author | Kanis, J Russell, G Smith, R |
| author_facet | Kanis, J Russell, G Smith, R |
| author_sort | Kanis, J |
| collection | OXFORD |
| description | Since several metabolites and analogues of vitamin D have become available, their physiological and therapeutic potential have been studied in various disorders of mineral metabolism, particularly those classically termed vitamin D resistant. In some instances this resistance appears to be due to defective metabolism of vitamin D or to defective target organ responses, but in others it is not. Although the precise effect of vitamin D or its metabolites on mineralization of bone is still unknown there is some evidence that the metabolites differ in their relative effects on intestine, bone, muscle and parathyroid glands. These differences may eventually have therapeutic values. At present the major advantage of 1α-hydroxylated derivatives of vitamin D over other compounds resides in their more rapid onset and reversal of action which makes them much easier and safer to use. |
| first_indexed | 2024-03-07T03:54:29Z |
| format | Journal article |
| id | oxford-uuid:c266c3eb-a85f-47a2-a00a-b8b4f07ccfdb |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:54:29Z |
| publishDate | 1977 |
| record_format | dspace |
| spelling | oxford-uuid:c266c3eb-a85f-47a2-a00a-b8b4f07ccfdb2022-03-27T06:08:40ZPhysiological and therapeutic differences between vitamin D, its metabolites and analoguesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c266c3eb-a85f-47a2-a00a-b8b4f07ccfdbSymplectic Elements at Oxford1977Kanis, JRussell, GSmith, RSince several metabolites and analogues of vitamin D have become available, their physiological and therapeutic potential have been studied in various disorders of mineral metabolism, particularly those classically termed vitamin D resistant. In some instances this resistance appears to be due to defective metabolism of vitamin D or to defective target organ responses, but in others it is not. Although the precise effect of vitamin D or its metabolites on mineralization of bone is still unknown there is some evidence that the metabolites differ in their relative effects on intestine, bone, muscle and parathyroid glands. These differences may eventually have therapeutic values. At present the major advantage of 1α-hydroxylated derivatives of vitamin D over other compounds resides in their more rapid onset and reversal of action which makes them much easier and safer to use. |
| spellingShingle | Kanis, J Russell, G Smith, R Physiological and therapeutic differences between vitamin D, its metabolites and analogues |
| title | Physiological and therapeutic differences between vitamin D, its metabolites and analogues |
| title_full | Physiological and therapeutic differences between vitamin D, its metabolites and analogues |
| title_fullStr | Physiological and therapeutic differences between vitamin D, its metabolites and analogues |
| title_full_unstemmed | Physiological and therapeutic differences between vitamin D, its metabolites and analogues |
| title_short | Physiological and therapeutic differences between vitamin D, its metabolites and analogues |
| title_sort | physiological and therapeutic differences between vitamin d its metabolites and analogues |
| work_keys_str_mv | AT kanisj physiologicalandtherapeuticdifferencesbetweenvitaminditsmetabolitesandanalogues AT russellg physiologicalandtherapeuticdifferencesbetweenvitaminditsmetabolitesandanalogues AT smithr physiologicalandtherapeuticdifferencesbetweenvitaminditsmetabolitesandanalogues |