Progression of myocardial fibrosis in hypertrophic cardiomyopathy: mechanisms and clinical implications

Progression of myocardial fibrosis in hypertrophic cardiomyopathy: mechanisms and clinical implications

<p><strong>Aims</strong> Myocardial fibrosis as detected by late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is a powerful prognostic marker in hypertrophic cardiomyopathy (HCM) and may be progressive. The precise mechanisms underlying fibrosis progression are...

Full description

Bibliographic Details
Main Authors:	Raman, B, Ariga, R, Spartera, M, Sivalokanathan, S, Chan, K, Dass, S, Petersen, SE, Daniels, MJ, Francis, J, Smillie, R, Lewandowski, AJ, Ohuma, EO, Rodgers, C, Kramer, CM, Mahmod, M, Watkins, H, Neubauer, S
Format:	Journal article
Published:	Oxford University Press 2018

Similar Items

Correlates of myocardial fibrosis in hypertrophic cardiomyopathy
by: Kramer, CM, et al.
Published: (2018)

Identification of myocardial disarray in patients with hypertrophic cardiomyopathy and ventricular arrhythmias
by: Ariga, R, et al.
Published: (2019)

Impaired left ventricular energy metabolism in hypertrophic cardiomyopathy is not due to fibrosis.
by: Petersen, SE, et al.
Published: (2009)

Diffusion tensor magnetic resonance imaging of myocardial disarray in hypertrophic cardiomyopathy
by: Ariga, R, et al.
Published: (2018)

Insights into mechanisms and clinical implications of myocardial fibrosis and its progression in hypertrophic cardiomyopathy
by: Raman, B
Published: (2019)

Adenosine stress T1 mapping: a novel contrast free method to assess myocardial perfusion and ischaemia in hypertrophic cardiomyopathy
by: Raman, B, et al.
Published: (2017)

Myocardial dysfunction in hypertrophic cardiomyopathy.
by: Ashrafian, H, et al.
Published: (2001)

Non-invasive imaging of myocardial disarray associates with ventricular arrhythmia in hypertrophic cardiomyopathy
by: Ariga, R, et al.
Published: (2017)

Myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy.
by: Dass, S, et al.
Published: (2012)

Blunted myocardial oxygenation response during vasodilator stress in patients with hypertrophic cardiomyopathy.
by: Karamitsos, T, et al.
Published: (2013)

Hypertrophic cardiomyopathy in Noonan Syndrome closely mimics familial hypertrophic cardiomyopathy due to sarcomeric mutations.
by: Hudsmith, L, et al.
Published: (2006)

Mechanisms and prognostic impact of myocardial ischaemia in hypertrophic cardiomyopathy
by: Coleman, JA, et al.
Published: (2023)

Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion.
by: Ashrafian, H, et al.
Published: (2003)

Assessment of myocardial fibre structure in hypertrophic cardiomyopathy with magnetic resonance diffusion tensor imaging
by: Ariga, R
Published: (2018)

Metabolomics in hypertrophic cardiomyopathy and other myocardial diseases
by: Pal, N
Published: (2015)

Response to letter regarding article, "myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy".
by: Dass, S, et al.
Published: (2013)

Discrepancy between pathological progression and clinical stability in a young patient with hypertrophic cardiomyopathy
by: Raman, B, et al.
Published: (2018)

Cardiac Steatosis Detected in Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy and Aortic Stenosis
by: Suttie, J, et al.
Published: (2011)

Sudden death in hypertrophic cardiomyopathy.
by: Watkins, H
Published: (2000)

In Both Hypertrophic And Dilated Cardiomyopathy, Non-contrast T1 Mapping Provides Myocardial Tissue Characterization Beyond That Achieved By Late Gadolinium Enhancement.
by: Dass, S, et al.
Published: (2011)

Incremental value of left atrial booster and reservoir strain in predicting atrial fibrillation in patients with hypertrophic cardiomyopathy: a cardiovascular magnetic resonance study
by: Raman, B, et al.
Published: (2021)

Further refining risk in hypertrophic cardiomyopathy with late gadolinium enhancement by CMR
by: Kramer, C, et al.
Published: (2018)

Electrocardiogram phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients vs. Purkinje-myocardial coupling abnormalities
by: Lyon, A, et al.
Published: (2018)

Patients with hypertrophic cardiomyopathy (HCM) and HCM gene carriers have attenuated myocardial oxygenation response to vasodilator stress - a potential mechanism for sudden cardiac death.
by: Dass, S, et al.
Published: (2012)

Metabolic perturbations in the pathogenesis of hypertrophic cardiomyopathy
by: Ashrafian, H, et al.
Published: (2005)

Data-driven modelling of mutational hotspots and in silico predictors in hypertrophic cardiomyopathy
by: Waring, A, et al.
Published: (2020)

The role of cardiac energy metabolism and during stress in hypertrophic and dilated cardiomyopathy.
by: Dass, S
Published: (2012)

ACUTE DERANGEMENT OF CARDIAC ENERGY METABOLISM AND OXYGENATION DURING STRESS IN HYPERTROPHIC CARDIOMYOPATHY-A POTENTIAL MECHANISM FOR SUDDEN CARDIAC DEATH
by: Dass, S, et al.
Published: (2012)

The genetics of hypertrophic cardiomyopathy: Teare redux.
by: Watkins, H, et al.
Published: (2008)

Evidence for microvascular dysfunction in hypertrophic cardiomyopathy: New insights from multiparametric MRI
by: Petersen, S, et al.
Published: (2007)

Distinct subgroups in hypertrophic cardiomyopathy in the NHLBI HCM registry
by: Neubauer, S, et al.
Published: (2019)

Distinct ECG phenotypes identified in hypertrophic cardiomyopathy using machine learning associate with arrhythmic risk markers
by: Lyon, A, et al.
Published: (2018)

Derangement of cardiac energy metabolism is acutely exacerbated during exercise in hypertrophic cardiomyopathy, independent of hypertrophy or late gadolinium burden
by: Dass, S, et al.
Published: (2012)

Linked genetic modifiers in hypertrophic cardiomyopathy
by: Ektisham, J, et al.
Published: (2004)

Distinct subgroups in hypertrophic cardiomyopathy in the NHLBI HCM Registry
by: Neubauer, S, et al.
Published: (2019)

Novel insights into diminished cardiac reserve in non-obstructive hypertrophic cardiomyopathy from four-dimensional flow cardiac magnetic resonance component analysis
by: Ashkir, Z, et al.
Published: (2023)

Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity
by: Harper, AR, et al.
Published: (2021)

Genetic clues to disease pathways in hypertrophic and dilated cardiomyopathies.
by: Watkins, H
Published: (2003)

Hypertrophic cardiomyopathy detection with artificial intelligence electrocardiography in international cohorts: an external validation study
by: Siontis, KC, et al.
Published: (2024)

Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa
by: Dass, S, et al.
Published: (2015)