Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort
Rationale: Exposure to air pollution during intrauterine development and through childhood may have lasting effects on respiratory health. Objectives: To investigate lung function at ages 8 and 15 years in relation to air pollution exposures during pregnancy, infancy and childhood in a UK population...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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American Thoracic Society
2020
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| _version_ | 1797093042079924224 |
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| author | Cai, Y Hansell, AL Granell, R Blangiardo, M Zottoli, M Fecht, D Gulliver, J Henderson, AJ Elliott, P |
| author_facet | Cai, Y Hansell, AL Granell, R Blangiardo, M Zottoli, M Fecht, D Gulliver, J Henderson, AJ Elliott, P |
| author_sort | Cai, Y |
| collection | OXFORD |
| description | Rationale: Exposure to air pollution during intrauterine development and through childhood may have lasting effects on respiratory health. Objectives: To investigate lung function at ages 8 and 15 years in relation to air pollution exposures during pregnancy, infancy and childhood in a UK population-based birth cohort. Methods: Individual exposures to source-specific particulate matter with diameter ≤10µm (PM10) during each trimester, 0-6 months, 7-12 months (1990-1993) and up to age 15 years (1991-2008) were examined in relation to %predicted Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) at ages 8(N=5,276) and 15(N=3,446) years, usinglinear regression models adjusted for potential confounders. A profile regression model was used to identify sensitive time periods. Measurements and Main Results: We did not find clear evidence for a sensitive exposure period for PM10 from road-traffic: at age 8 years, 1µg/m3 higher exposure during the first trimester was associated with lower %predicted of FEV1(-0.826, 95%CI:-1.357 to -0.296) and FVC(-0.817, 95%CI:-1.357 to -0.276), but similar associations were seen for exposures for other trimesters, 0-6 months, 7-12 months, and 0-7 years. Associations were stronger among boys, children whose mother had a lower education level or smoked during pregnancy. For PM10 from all sources, the third trimester was associated with lower %predicted of FVC (-1.312, 95%CI: -2.100 to -0.525). At age 15 years, no adverse associations were seen with lung function. Conclusions: Exposure to road-traffic PM10 during pregnancy may result in small but significant reductions in lung function at age 8 years.
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| first_indexed | 2024-03-07T03:54:40Z |
| format | Journal article |
| id | oxford-uuid:c275d09a-9474-4ab5-89c3-7b9070371920 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:54:40Z |
| publishDate | 2020 |
| publisher | American Thoracic Society |
| record_format | dspace |
| spelling | oxford-uuid:c275d09a-9474-4ab5-89c3-7b90703719202022-03-27T06:09:13ZPrenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c275d09a-9474-4ab5-89c3-7b9070371920EnglishSymplectic ElementsAmerican Thoracic Society2020Cai, YHansell, ALGranell, RBlangiardo, MZottoli, MFecht, DGulliver, JHenderson, AJElliott, PRationale: Exposure to air pollution during intrauterine development and through childhood may have lasting effects on respiratory health. Objectives: To investigate lung function at ages 8 and 15 years in relation to air pollution exposures during pregnancy, infancy and childhood in a UK population-based birth cohort. Methods: Individual exposures to source-specific particulate matter with diameter ≤10µm (PM10) during each trimester, 0-6 months, 7-12 months (1990-1993) and up to age 15 years (1991-2008) were examined in relation to %predicted Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) at ages 8(N=5,276) and 15(N=3,446) years, usinglinear regression models adjusted for potential confounders. A profile regression model was used to identify sensitive time periods. Measurements and Main Results: We did not find clear evidence for a sensitive exposure period for PM10 from road-traffic: at age 8 years, 1µg/m3 higher exposure during the first trimester was associated with lower %predicted of FEV1(-0.826, 95%CI:-1.357 to -0.296) and FVC(-0.817, 95%CI:-1.357 to -0.276), but similar associations were seen for exposures for other trimesters, 0-6 months, 7-12 months, and 0-7 years. Associations were stronger among boys, children whose mother had a lower education level or smoked during pregnancy. For PM10 from all sources, the third trimester was associated with lower %predicted of FVC (-1.312, 95%CI: -2.100 to -0.525). At age 15 years, no adverse associations were seen with lung function. Conclusions: Exposure to road-traffic PM10 during pregnancy may result in small but significant reductions in lung function at age 8 years. |
| spellingShingle | Cai, Y Hansell, AL Granell, R Blangiardo, M Zottoli, M Fecht, D Gulliver, J Henderson, AJ Elliott, P Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort |
| title | Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort |
| title_full | Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort |
| title_fullStr | Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort |
| title_full_unstemmed | Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort |
| title_short | Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort |
| title_sort | prenatal early life and childhood exposure to air pollution and lung function the alspac cohort |
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