The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.
We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiv...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
National Academy of Sciences
2003
|
| _version_ | 1797093078342828032 |
|---|---|
| author | Pavlović, D Neville, D Argaud, O Blumberg, B Dwek, R Fischer, W Zitzmann, N |
| author_facet | Pavlović, D Neville, D Argaud, O Blumberg, B Dwek, R Fischer, W Zitzmann, N |
| author_sort | Pavlović, D |
| collection | OXFORD |
| description | We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy. |
| first_indexed | 2024-03-07T03:55:09Z |
| format | Journal article |
| id | oxford-uuid:c2a05af2-875f-4604-95f9-0ac92f6a93ce |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:55:09Z |
| publishDate | 2003 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | oxford-uuid:c2a05af2-875f-4604-95f9-0ac92f6a93ce2022-03-27T06:10:19ZThe hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c2a05af2-875f-4604-95f9-0ac92f6a93ceEnglishSymplectic Elements at OxfordNational Academy of Sciences2003Pavlović, DNeville, DArgaud, OBlumberg, BDwek, RFischer, WZitzmann, NWe show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy. |
| spellingShingle | Pavlović, D Neville, D Argaud, O Blumberg, B Dwek, R Fischer, W Zitzmann, N The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. |
| title | The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. |
| title_full | The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. |
| title_fullStr | The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. |
| title_full_unstemmed | The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. |
| title_short | The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. |
| title_sort | hepatitis c virus p7 protein forms an ion channel that is inhibited by long alkyl chain iminosugar derivatives |
| work_keys_str_mv | AT pavlovicd thehepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT nevilled thehepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT argaudo thehepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT blumbergb thehepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT dwekr thehepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT fischerw thehepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT zitzmannn thehepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT pavlovicd hepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT nevilled hepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT argaudo hepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT blumbergb hepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT dwekr hepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT fischerw hepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives AT zitzmannn hepatitiscvirusp7proteinformsanionchannelthatisinhibitedbylongalkylchainiminosugarderivatives |