Tumour glycolysis: the many faces of HIF.
We present a model for tumour metabolism that incorporates both microenvironmental (extracellular) and oncogenic (intracellular) influences. We explore the effects of the interaction between the hypoxic microenvironment and intracellular signalling on the glycolytic response of tumour tissue, findin...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2008
|
| _version_ | 1797093113133531136 |
|---|---|
| author | Kelly, C Smallbone, K Brady, M |
| author_facet | Kelly, C Smallbone, K Brady, M |
| author_sort | Kelly, C |
| collection | OXFORD |
| description | We present a model for tumour metabolism that incorporates both microenvironmental (extracellular) and oncogenic (intracellular) influences. We explore the effects of the interaction between the hypoxic microenvironment and intracellular signalling on the glycolytic response of tumour tissue, finding that the glycolytic state is dependent on a delicately balanced interplay between the cellular hypoxic response, mediated by hypoxia-inducible factor-1alpha (HIF-1alpha), and growth-factor signalling cascades, which are frequently mutated in cancers. Our findings demonstrate the importance of considering both environmental and intracellular regulation when interpreting tumour metabolism for diagnostic or prognostic purposes. To illustrate this, we demonstrate the potential impact of this multi-factorial regulation on the kinetics of radiolabelled glucose analogues, used in positron emission tomography (PET). |
| first_indexed | 2024-03-07T03:55:40Z |
| format | Journal article |
| id | oxford-uuid:c2cb292b-e67f-4e2c-bfd0-dad5c1f4a46a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:55:40Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:c2cb292b-e67f-4e2c-bfd0-dad5c1f4a46a2022-03-27T06:11:34ZTumour glycolysis: the many faces of HIF.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c2cb292b-e67f-4e2c-bfd0-dad5c1f4a46aEnglishSymplectic Elements at Oxford2008Kelly, CSmallbone, KBrady, MWe present a model for tumour metabolism that incorporates both microenvironmental (extracellular) and oncogenic (intracellular) influences. We explore the effects of the interaction between the hypoxic microenvironment and intracellular signalling on the glycolytic response of tumour tissue, finding that the glycolytic state is dependent on a delicately balanced interplay between the cellular hypoxic response, mediated by hypoxia-inducible factor-1alpha (HIF-1alpha), and growth-factor signalling cascades, which are frequently mutated in cancers. Our findings demonstrate the importance of considering both environmental and intracellular regulation when interpreting tumour metabolism for diagnostic or prognostic purposes. To illustrate this, we demonstrate the potential impact of this multi-factorial regulation on the kinetics of radiolabelled glucose analogues, used in positron emission tomography (PET). |
| spellingShingle | Kelly, C Smallbone, K Brady, M Tumour glycolysis: the many faces of HIF. |
| title | Tumour glycolysis: the many faces of HIF. |
| title_full | Tumour glycolysis: the many faces of HIF. |
| title_fullStr | Tumour glycolysis: the many faces of HIF. |
| title_full_unstemmed | Tumour glycolysis: the many faces of HIF. |
| title_short | Tumour glycolysis: the many faces of HIF. |
| title_sort | tumour glycolysis the many faces of hif |
| work_keys_str_mv | AT kellyc tumourglycolysisthemanyfacesofhif AT smallbonek tumourglycolysisthemanyfacesofhif AT bradym tumourglycolysisthemanyfacesofhif |