Pleiotropic analysis of lung cancer and blood triglycerides.
Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted pleiotropic analysis of genome-wide association studies of lung cancer (12 160 lun...
| Glavni autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Jezik: | English |
| Izdano: |
Oxford University Press
2016
|
| _version_ | 1826295096280088576 |
|---|---|
| author | Zuber, V Marconett, C Shi, J Hua, X Wheeler, W Yang, C Song, L Dale, A Laplana, M Risch, A Witoelar, A Thompson, W Schork, A Bettella, F Wang, Y Djurovic, S Zhou, B Borok, Z van der Heijden, H de Graaf, J Swinkels, D Aben, K McKay, J Hung, R Bikeböller, H Stevens, V Albanes, D Caporaso, N Han, Y Wei, Y Panadero, M Mayordomo, J Christiani, D Kiemeney, L Andreassen, O Houlston, R Amos, C Chatterjee, N Laird-Offringa, I Mills, I Landi, M |
| author_facet | Zuber, V Marconett, C Shi, J Hua, X Wheeler, W Yang, C Song, L Dale, A Laplana, M Risch, A Witoelar, A Thompson, W Schork, A Bettella, F Wang, Y Djurovic, S Zhou, B Borok, Z van der Heijden, H de Graaf, J Swinkels, D Aben, K McKay, J Hung, R Bikeböller, H Stevens, V Albanes, D Caporaso, N Han, Y Wei, Y Panadero, M Mayordomo, J Christiani, D Kiemeney, L Andreassen, O Houlston, R Amos, C Chatterjee, N Laird-Offringa, I Mills, I Landi, M |
| author_sort | Zuber, V |
| collection | OXFORD |
| description | Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted pleiotropic analysis of genome-wide association studies of lung cancer (12 160 lung cancer case patients and 16 838 control subjects) and cardiovascular disease risk factors (blood lipids from 188 577 subjects, type 2 diabetes from 148 821 subjects, body mass index from 123 865 subjects, and smoking phenotypes from 74 053 subjects). We found that 6p22.1 (rs6904596, ZNF184) was associated with both lung cancer (P = 5.50x10(-6)) and blood triglycerides (P = 1.39x10(-5)). We replicated the association in 6097 lung cancer case patients and 204 657 control subjects (P = 2.40 × 10(-4)) and in 71 113 subjects with triglycerides data (P = .01). rs6904596 reached genome-wide significance in lung cancer meta-analysis (odds ratio = 1.15, 95% confidence interval = 1.10 to 1.21 ,: Pcombined = 5.20x10(-9)). The large sample size provided by the lipid GWAS data and the shared genetic risk factors between the two traits contributed to the uncovering of a hitherto unidentified genetic locus for lung cancer. |
| first_indexed | 2024-03-07T03:55:51Z |
| format | Journal article |
| id | oxford-uuid:c2d719b5-cfe2-4e3e-af26-f840d822c7f3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:55:51Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:c2d719b5-cfe2-4e3e-af26-f840d822c7f32022-03-27T06:12:05ZPleiotropic analysis of lung cancer and blood triglycerides.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c2d719b5-cfe2-4e3e-af26-f840d822c7f3EnglishSymplectic Elements at OxfordOxford University Press2016Zuber, VMarconett, CShi, JHua, XWheeler, WYang, CSong, LDale, ALaplana, MRisch, AWitoelar, AThompson, WSchork, ABettella, FWang, YDjurovic, SZhou, BBorok, Zvan der Heijden, Hde Graaf, JSwinkels, DAben, KMcKay, JHung, RBikeböller, HStevens, VAlbanes, DCaporaso, NHan, YWei, YPanadero, MMayordomo, JChristiani, DKiemeney, LAndreassen, OHoulston, RAmos, CChatterjee, NLaird-Offringa, IMills, ILandi, MEpidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted pleiotropic analysis of genome-wide association studies of lung cancer (12 160 lung cancer case patients and 16 838 control subjects) and cardiovascular disease risk factors (blood lipids from 188 577 subjects, type 2 diabetes from 148 821 subjects, body mass index from 123 865 subjects, and smoking phenotypes from 74 053 subjects). We found that 6p22.1 (rs6904596, ZNF184) was associated with both lung cancer (P = 5.50x10(-6)) and blood triglycerides (P = 1.39x10(-5)). We replicated the association in 6097 lung cancer case patients and 204 657 control subjects (P = 2.40 × 10(-4)) and in 71 113 subjects with triglycerides data (P = .01). rs6904596 reached genome-wide significance in lung cancer meta-analysis (odds ratio = 1.15, 95% confidence interval = 1.10 to 1.21 ,: Pcombined = 5.20x10(-9)). The large sample size provided by the lipid GWAS data and the shared genetic risk factors between the two traits contributed to the uncovering of a hitherto unidentified genetic locus for lung cancer. |
| spellingShingle | Zuber, V Marconett, C Shi, J Hua, X Wheeler, W Yang, C Song, L Dale, A Laplana, M Risch, A Witoelar, A Thompson, W Schork, A Bettella, F Wang, Y Djurovic, S Zhou, B Borok, Z van der Heijden, H de Graaf, J Swinkels, D Aben, K McKay, J Hung, R Bikeböller, H Stevens, V Albanes, D Caporaso, N Han, Y Wei, Y Panadero, M Mayordomo, J Christiani, D Kiemeney, L Andreassen, O Houlston, R Amos, C Chatterjee, N Laird-Offringa, I Mills, I Landi, M Pleiotropic analysis of lung cancer and blood triglycerides. |
| title | Pleiotropic analysis of lung cancer and blood triglycerides. |
| title_full | Pleiotropic analysis of lung cancer and blood triglycerides. |
| title_fullStr | Pleiotropic analysis of lung cancer and blood triglycerides. |
| title_full_unstemmed | Pleiotropic analysis of lung cancer and blood triglycerides. |
| title_short | Pleiotropic analysis of lung cancer and blood triglycerides. |
| title_sort | pleiotropic analysis of lung cancer and blood triglycerides |
| work_keys_str_mv | AT zuberv pleiotropicanalysisoflungcancerandbloodtriglycerides AT marconettc pleiotropicanalysisoflungcancerandbloodtriglycerides AT shij pleiotropicanalysisoflungcancerandbloodtriglycerides AT huax pleiotropicanalysisoflungcancerandbloodtriglycerides AT wheelerw pleiotropicanalysisoflungcancerandbloodtriglycerides AT yangc pleiotropicanalysisoflungcancerandbloodtriglycerides AT songl pleiotropicanalysisoflungcancerandbloodtriglycerides AT dalea pleiotropicanalysisoflungcancerandbloodtriglycerides AT laplanam pleiotropicanalysisoflungcancerandbloodtriglycerides AT rischa pleiotropicanalysisoflungcancerandbloodtriglycerides AT witoelara pleiotropicanalysisoflungcancerandbloodtriglycerides AT thompsonw pleiotropicanalysisoflungcancerandbloodtriglycerides AT schorka pleiotropicanalysisoflungcancerandbloodtriglycerides AT bettellaf pleiotropicanalysisoflungcancerandbloodtriglycerides AT wangy pleiotropicanalysisoflungcancerandbloodtriglycerides AT djurovics pleiotropicanalysisoflungcancerandbloodtriglycerides AT zhoub pleiotropicanalysisoflungcancerandbloodtriglycerides AT borokz pleiotropicanalysisoflungcancerandbloodtriglycerides AT vanderheijdenh pleiotropicanalysisoflungcancerandbloodtriglycerides AT degraafj pleiotropicanalysisoflungcancerandbloodtriglycerides AT swinkelsd pleiotropicanalysisoflungcancerandbloodtriglycerides AT abenk pleiotropicanalysisoflungcancerandbloodtriglycerides AT mckayj pleiotropicanalysisoflungcancerandbloodtriglycerides AT hungr pleiotropicanalysisoflungcancerandbloodtriglycerides AT bikebollerh pleiotropicanalysisoflungcancerandbloodtriglycerides AT stevensv pleiotropicanalysisoflungcancerandbloodtriglycerides AT albanesd pleiotropicanalysisoflungcancerandbloodtriglycerides AT caporason pleiotropicanalysisoflungcancerandbloodtriglycerides AT hany pleiotropicanalysisoflungcancerandbloodtriglycerides AT weiy pleiotropicanalysisoflungcancerandbloodtriglycerides AT panaderom pleiotropicanalysisoflungcancerandbloodtriglycerides AT mayordomoj pleiotropicanalysisoflungcancerandbloodtriglycerides AT christianid pleiotropicanalysisoflungcancerandbloodtriglycerides AT kiemeneyl pleiotropicanalysisoflungcancerandbloodtriglycerides AT andreasseno pleiotropicanalysisoflungcancerandbloodtriglycerides AT houlstonr pleiotropicanalysisoflungcancerandbloodtriglycerides AT amosc pleiotropicanalysisoflungcancerandbloodtriglycerides AT chatterjeen pleiotropicanalysisoflungcancerandbloodtriglycerides AT lairdoffringai pleiotropicanalysisoflungcancerandbloodtriglycerides AT millsi pleiotropicanalysisoflungcancerandbloodtriglycerides AT landim pleiotropicanalysisoflungcancerandbloodtriglycerides |