Pre-metastatic niches: organ-specific homes for metastases
It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Research
2017
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| _version_ | 1797093145120342016 |
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| author | Peinado, H Zhang, H Matei, I Costa-Silva, B Hoshino, A Rodrigues, G Psaila, B Kaplan, R Bromberg, J Kang, Y Bissell, M Cox, T Giaccia, A Erler, J Hiratsuka, S Ghajar, C Lyden, D |
| author_facet | Peinado, H Zhang, H Matei, I Costa-Silva, B Hoshino, A Rodrigues, G Psaila, B Kaplan, R Bromberg, J Kang, Y Bissell, M Cox, T Giaccia, A Erler, J Hiratsuka, S Ghajar, C Lyden, D |
| author_sort | Peinado, H |
| collection | OXFORD |
| description | It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche. |
| first_indexed | 2024-03-07T03:56:07Z |
| format | Journal article |
| id | oxford-uuid:c2ec1d95-5167-4047-a2b4-d01fb271ceb1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:56:07Z |
| publishDate | 2017 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:c2ec1d95-5167-4047-a2b4-d01fb271ceb12022-03-27T06:12:40ZPre-metastatic niches: organ-specific homes for metastasesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c2ec1d95-5167-4047-a2b4-d01fb271ceb1EnglishSymplectic Elements at OxfordNature Research2017Peinado, HZhang, HMatei, ICosta-Silva, BHoshino, ARodrigues, GPsaila, BKaplan, RBromberg, JKang, YBissell, MCox, TGiaccia, AErler, JHiratsuka, SGhajar, CLyden, DIt is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche. |
| spellingShingle | Peinado, H Zhang, H Matei, I Costa-Silva, B Hoshino, A Rodrigues, G Psaila, B Kaplan, R Bromberg, J Kang, Y Bissell, M Cox, T Giaccia, A Erler, J Hiratsuka, S Ghajar, C Lyden, D Pre-metastatic niches: organ-specific homes for metastases |
| title | Pre-metastatic niches: organ-specific homes for metastases |
| title_full | Pre-metastatic niches: organ-specific homes for metastases |
| title_fullStr | Pre-metastatic niches: organ-specific homes for metastases |
| title_full_unstemmed | Pre-metastatic niches: organ-specific homes for metastases |
| title_short | Pre-metastatic niches: organ-specific homes for metastases |
| title_sort | pre metastatic niches organ specific homes for metastases |
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